The therapeutic potential of regulatory T cells for the treatment of autoimmune disease

被引:80
作者
Bluestone, Jeffrey A. [1 ]
Trotta, Eleonora [1 ]
Xu, Daqi [1 ]
机构
[1] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
关键词
autoimmunity; cell therapy; organ transplantation; peripheral tolerance; regulatory T cells; suppressor cells; ANTI-THYMOCYTE GLOBULIN; GROWTH-FACTOR-BETA; RHEUMATOID-ARTHRITIS; FOXP3; EXPRESSION; TREG CELLS; TGF-BETA; SUPPRESSOR FUNCTION; SELF-ANTIGEN; NOD MICE; INDUCTION;
D O I
10.1517/14728222.2015.1037282
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Immune tolerance remains the holy grail of therapeutic immunology in the fields of organ and tissue transplant rejection, autoimmune diseases, and allergy and asthma. We have learned that FoxP3(+)CD4(+) regulatory T cells play a vital role in both the induction and maintenance of self-tolerance. Areas covered: In this opinion piece, we highlight regulatory T cells (Treg) cell biology and novel immune treatments to take advantage of these cells as potent therapeutics. We discuss the potential to utilize Treg and Treg-friendly therapies to replace current general immunosuppressives and induce tolerance as a path towards a drug-free existence without associated toxicities. Expert opinion: Finally, we opine on the fact that biomedicine sits on the cusp of a new revolution: the use of human cells as versatile therapeutic engines. We highlight the challenges and opportunities associated with the development of a foundational cellular engineering science that provides a systematic framework for safely and predictably regulating cellular behaviors. Although Treg therapy has become a legitimate clinical treatment, development of the therapy will require a better understanding of the underlying Treg biology, manufacturing advances to promote cost effectiveness and combinations with other drugs to alter the pathogenicity/regulatory balance.
引用
收藏
页码:1091 / 1103
页数:13
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