Trends in biomedical engineering: focus on Smart Bio-Materials and Drug Delivery

被引：30

作者：

Tanzi, Maria Cristina ^{[1
]}

Bozzini, Sabrina ^{[1
]}

Candiani, Gabriele ^{[2
]}

Cigada, Alberto ^{[2
]}

De Nardo, Luigi ^{[2
]}

Fare, Silvia ^{[1
]}

Ganazzoli, Fabio ^{[2
]}

Gastaldi, Dario ^{[4
]}

Levi, Marinella ^{[2
]}

Metrangolo, Pierangelo ^{[2
]}

Migliavacca, Francesco ^{[4
]}

Osellame, Roberto ^{[3
]}

Petrini, Paola ^{[1
]}

Raffaini, Giuseppina ^{[2
]}

Resnati, Giuseppe ^{[2
]}

Vena, Pasquale ^{[4
]}

Vesentini, Simone ^{[1
]}

Zunino, Paolo ^{[5
]}

机构：

[1] Politecn Milan, Dipartimento Bioingn, I-20133 Milan, Italy

[2] Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, I-20133 Milan, Italy

[3] Politecn Milan, Dept Phys, I-20133 Milan, Italy

[4] Politecn Milan, Dept Struct Engn, I-20133 Milan, Italy

[5] Politecn Milan, Dept Math, I-20133 Milan, Italy

来源：

JOURNAL OF APPLIED BIOMATERIALS & BIOMECHANICS | 2011年 / 9卷 / 02期

关键词：

Biodegradable stents; Drug delivery; Gene delivery; Shape memory polymers; Surface modeling; Surface modification; COMPUTER-SIMULATION; PROTEIN ADSORPTION; SURFACE; MODEL; BIOMATERIALS; PLASMA;

D O I：

10.5301/JABB.2011.8563

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The present article reviews on different research lines, namely: drug and gene delivery, surface modification/modeling, design of advanced materials (shape memory polymers and biodegradable stents), presently developed at Politecnico di Milano, Italy. For gene delivery, non-viral polycationic-branched polyethylenimine (b-PEI) polyplexes are coated with pectin, an anionic polysaccharide, to enhance the polyplex stability and decrease b-PEI cytotoxicity. Perfluorinated materials, specifically perfluoroether, and perfluoro-polyether fluids are proposed as ultrasound contrast agents and smart agents for drug delivery. Non-fouling, self-assembled PEG-based monolayers are developed on titanium surfaces with the aim of drastically reducing cariogenic bacteria adhesion on dental implants. Femtosecond laser microfabrication is used for selectively and spatially tuning the wettability of polymeric biomaterials and the effects of femtosecond laser ablation on the surface properties of polymethylmethacrylate are studied. Innovative functionally graded Alumina-Ti coatings for wear resistant articulating surfaces are deposited with PLD and characterized by means of a combined experimental and computational approach. Protein adsorption on biomaterials surfaces with an unlike wettability and surface-modification induced by pre-adsorbed proteins are studied by atomistic computer simulations. A study was performed on the fabrication of porous Shape Memory Polymeric structures and on the assessment of their potential application in minimally invasive surgical procedures. A model of magnesium (alloys) degradation, in a finite element framework analysis, and a bottom-up multiscale analysis for modeling the degradation mechanism of PLA matrices was developed, with the aim of providing valuable tools for the design of bioresorbable stents.

引用

页码：87 / 97

页数：11

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