Immune disease expressed in liver and platelets in an adolescent: a case report

被引：3

作者：

Antunes, Henedina ^{[1
,2
,3
]}

Rocha, Ruben ^{[1
,2
]}

Silva, Nicole ^{[1
,2
]}

Pontes, Teresa ^{[1
,2
]}

Antunes, Ana ^{[1
,2
]}

Martins, Sofia ^{[1
,2
]}

机构：

[1] Braga Hosp, Dept Pediat, Adolescents Unit, Braga, Portugal

[2] Braga Hosp, Dept Pediat, Gastrenterol Hepatol & Nutr Unit, Braga, Portugal

[3] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4709057 Braga, Portugal

来源：

ITALIAN JOURNAL OF PEDIATRICS | 2010年 / 36卷

关键词：

IDIOPATHIC THROMBOCYTOPENIC PURPURA; AUTOIMMUNE HEPATITIS; SJOGRENS-SYNDROME; DIAGNOSIS;

D O I：

10.1186/1824-7288-36-42

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report a case of a 15-year-old boy with autoimmune hepatitis lacking common serologic markers and normal gammaglobulinemia associated with immune thrombocytopenia and family history of psoriasis. He presented to our department with a 4-year history of a cervical posterior lymphadenopathy and recent petechiae. Previous laboratory results 6 months before already showed hepatocellular injury. After exclusion of other causes, the diagnosis of autoimmune hepatitis was made based on clinical grounds, associated immune disorder and histological features of liver biopsy. The authors alert for this atypical presentation of autoimmune hepatitis and associated immune thrombocytopenia.

引用

页数：4

共 16 条

[1] International Autoimmune Hepatitis Group Report:: review of criteria for diagnosis of autoimmune hepatitis [J].

Alvarez, E ;

Berg, PA ;

Bianchi, FB ;

Bianchi, L ;

Burroughs, AK ;

Cancado, EL ;

Chapman, RW ;

Cooksley, WGE ;

Czaja, AJ ;

Desmet, VJ ;

Donaldson, RT ;

Eddleston, ALWF ;

Fainboim, L ;

Heathcote, J ;

Homberg, JC ;

Hoofnagle, JH ;

Kakumu, S ;

Krawitt, EL ;

Mackay, IR ;

MacSween, RNM ;

Maddrey, WC ;

Manns, MP ;

McFarlane, IG ;

zum Büschenfelde, KHM ;

Mieli-Vergani, G ;

Nakanuma, Y ;

Nishioka, M ;

Penner, E ;

Porta, G ;

Portmann, BC ;

Reed, WD ;

Rodes, J ;

Schalm, SW ;

Scheuer, PJ ;

Schrumpf, E ;

Seki, T ;

Toda, G ;

Tsuji, T ;

Tygstrup, N ;

Vergani, D ;

Zeniya, M .

JOURNAL OF HEPATOLOGY, 1999, 31 (05) :929-938

[2]

Balakrishnan C, 1998, J Assoc Physicians India, V46, P431

[3] Diagnosis and treatment of autoimmune hepatitis [J].

Czaja, AJ ;

Freesel, DK .

HEPATOLOGY, 2002, 36 (02) :479-497

[4]

Czaja Albert J, 2006, MedGenMed, V8, P55

[5]

DUCHINI A, 2001, AM J GASTROENTEROL, V96, P3447

[6]

Romero RG, 2007, REV ESP ENFERM DIG, V99, P255

[7] Simplified criteria for the diagnosis of autoimmune hepatitis [J].

Hennes, Elke M. ;

Zeniya, Mikio ;

Czaja, Albert. J. ;

Pares, Albert ;

Dalekos, George N. ;

Krawitt, Edward L. ;

Bittencourt, Paulo L. ;

Porta, Gilda ;

Boberg, Kirsten M. ;

Hofer, Harald ;

Bianchi, Francesco B. ;

Shibata, Minoru ;

Schramm, Christoph ;

de Torres, Barbara Eisenmann ;

Galle, Peter R. ;

McFarlane, Ian ;

Dienes, Hans-Peter ;

Lohse, Ansgar W. .

HEPATOLOGY, 2008, 48 (01) :169-176

[8]

KAWANO N, ACTA MED NAGASAKI, V48, P179

[9] Medical progress: Autoimmune hepatitis [J].

Krawitt, EL .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (01) :54-66

[10]

Persico M, 1996, ITAL J GASTROENTEROL, V28, P340

← 1 2 →