Artemisinin-Resistant Malaria as a Global Catastrophic Biological Threat

被引：6
作者：
Ricotta, Emily [1 ,2 ]
Kwan, Jennifer [1 ]
机构：
[1] NIAID, Div Intramural Res, NIH, Quarters 15B-1,8 West Dr, Bethesda, MD 20892 USA
[2] Kelly Govt Solut, Bethesda, MD USA
来源：
GLOBAL CATASTROPHIC BIOLOGICAL RISKS | 2019年 / 424卷
基金：
美国国家卫生研究院;
关键词：
INTERMITTENT PREVENTIVE THERAPY; PLASMODIUM-FALCIPARUM; DRUG-RESISTANCE; VACCINE; EFFICACY; COMBINATION; IMPACT; POLYMORPHISMS; MEFLOQUINE; MECHANISM;
D O I：
10.1007/82_2019_163
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The global spread of artemisinin resistance brings with it the threat of incurable malaria. Already, this disease threatens over 219 million lives per year and causes 5-6% losses in GDP in endemic areas, even with current advances in prevention and treatment. This chapter discusses the currently tenuous position we are in globally, and the impact that could be seen if artemisinin treatment is lost, whether due to the unchecked spread of K13 mutations or poor global investment in treatment and prevention advances. Artemisinin is the backbone of current ACT treatment programs and severe malarial treatment; without it, the success of future malaria eradication programs will be in jeopardy.
引用
收藏
页码：33 / 57
页数：25
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