Moonlighting glyceraldehyde-3-phosphate dehydrogenase: posttranslational modification, protein and nucleic acid interactions in normal cells and in human pathology

被引：23

作者：

Sirover, Michael A. ^{[1
]}

机构：

[1] Temple Univ, Lewis Katz Sch Med, Dept Pharmacol, 3240 North Broad St, Philadelphia, PA 19140 USA

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2020年 / 55卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Glyceraldehyde-3-phosphate dehydrogenase; moonlighting protein; posttranslational modification; mRNA stability; DNA structure; URACIL DNA-GLYCOSYLASE; MESSENGER-RNA STABILITY; OVARIAN-CANCER CELLS; ALZHEIMERS-DISEASE; POSTTRANSCRIPTIONAL REGULATION; ENDOTHELIN-1; EXPRESSION; 3'-UNTRANSLATED REGION; PHYSICAL ASSOCIATION; BINDING PROTEINS; POLYMERASE-II;

D O I：

10.1080/10409238.2020.1787325

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) exhibits multiple functions separate and distinct from its historic role in energy production. Further, it exhibits dynamic changes in its subcellular localization which is an a priori requirement for its multiple activities. Separately, moonlighting GAPDH may function in the pathology of human disease, involved in tumorigenesis, diabetes, and age-related neurodegenerative disorders. It is suggested that moonlighting GAPDH function may be related to specific modifications of its protein structure as well as the formation of GAPDH protein: protein or GAPDH protein: nucleic acid complexes.

引用

页码：354 / 371

页数：18

共 77 条

[1] Oxidation of glyceraidehyde-3-phosphate dehydrogenase enhances its binding to nucleic acids [J].

Arutyunova, EI ;

Danshina, PV ;

Domnina, LV ;

Pleten, AP ;

Muronetz, VI .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 307 (03) :547-552

[2] Human Glyceraldehyde-3-phosphate Dehydrogenase Plays a Direct Role in Reactivating Oxidized Forms of the DNA Repair Enzyme APE1 [J].

Azam, Sonish ;

Jouvet, Nathalie ;

Jilani, Arshad ;

Vongsamphanh, Ratsavarinh ;

Yang, Xiaoming ;

Yang, Stephen ;

Ramotar, Dindial .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (45) :30632-30641

[3] Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase [J].

Backlund, Michael ;

Paukku, Kirsi ;

Daviet, Laurent ;

De Boer, Rudolf A. ;

Valo, Erkka ;

Hautaniemi, Sampsa ;

Kalkkinen, Nisse ;

Ehsan, Afshin ;

Kontula, Kimmo K. ;

Lehtonen, Jukka Y. A. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (07) :2346-2358

[4] Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH [J].

Bae, Y ;

Hara, MR ;

Cascio, MB ;

Wellington, CL ;

Hayden, MR ;

Ross, CA ;

Ha, HC ;

Li, XJ ;

Snyder, SH ;

Sawa, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3405-3409

[5] URACIL DNA-GLYCOSYLASE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IS AN AP(4)A BINDING-PROTEIN [J].

BAXI, MD ;

VISHWANATHA, JK .

BIOCHEMISTRY, 1995, 34 (30) :9700-9707

[6] Genetic control of biochemical reactions in neurospora [J].

Beadle, GW ;

Tatum, EL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1941, 27 :499-506

[7] Glyceraldehyde-3-phosphate dehydrogenase binds to the AU-rich 3′ untranslated region of colony-stimulating factor-1 (CSF-1) messenger RNA in human ovarian cancer cells:: Possible role in CSF-1 posttranscriptional regulation and tumor phenotype [J].

Bonafé, N ;

Gilmore-Hebert, M ;

Folk, NL ;

Azodi, M ;

Zhou, Y ;

Chambers, SK .

CANCER RESEARCH, 2005, 65 (09) :3762-3771

[8] A novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress [J].

Brown, VM ;

Krynetski, EY ;

Krynetskaia, NF ;

Grieger, D ;

Mukatira, ST ;

Murti, KG ;

Slaughter, CA ;

Park, HW ;

Evans, WE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) :5984-5992

[9] Huntington and DRPLA proteins selectively interact with the enzyme GAPDH [J].

Burke, JR ;

Enghild, JJ ;

Martin, ME ;

Jou, YS ;

Myers, RM ;

Roses, AD ;

Vance, JM ;

Strittmatter, WJ .

NATURE MEDICINE, 1996, 2 (03) :347-350

[10]

Chakravarti R, 2010, J BIOL CHEM, V287, P16179

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