A new tetrahydroprotoberberine N-oxide alkaloid and anti-platelet aggregation constituents of Corydalis tashiroi

被引：45

作者：

Chen, JJ

Chang, YL

Teng, CM

Lin, WY

Chen, YC

Chen, IS ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Pharmaceut Sci, Kaohsiung, Taiwan

[2] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan

[3] Tajen Inst Technol, Dept Pharm, Pingtung, Taiwan

来源：

PLANTA MEDICA | 2001年 / 67卷 / 05期

关键词：

Corydalis tashiroi; Fumariaceae; alkaloids; berberine; tetrahydroprotoberberine N-oxide; (-)-cis-isocorypalmine N-oxide; anti-platelet aggregation activity;

D O I：

10.1055/s-2001-15820

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new tetrahydroprotoberberine N-oxide alkaloid, (-)-cis-isocorypalmine N-oxide (1), together with two known compounds, 6-methoxydihydrosanguinarine (2) and norjuziphine (3), were isolated in continuing studies of the entire Formosan Corydalis tashiroi plant. The structures of these three compounds were determined through spectral analyses. In addition, compounds 1, 2, 3 and the seven alkaloids previously reported: (-)-cis-corydalmine N-oxide, (-)-trans-corydalmine N-oxide, (-)-trans-isocorypalmine N-oxide, scoulerine, protopine, oxysanguinarine and corydalmine. were found to possess antiplatelet aggregation activity.

引用

页码：423 / 427

页数：5

共 9 条

[1] New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi [J].