Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent against Different Cancer Cell Lines

被引：22

作者：

Keta, Otilija ^{[1
]}

Deljanin, Milena ^{[2
]}

Petkovic, Vladana ^{[1
]}

Zdunic, Gordana ^{[3
]}

Jankovic, Teodora ^{[3
]}

Zivkovic, Jelena ^{[3
]}

Ristic-Fira, Aleksandra ^{[1
]}

Petrovic, Ivan ^{[1
]}

Savikin, Katarina ^{[3
]}

机构：

[1] Univ Belgrade, Vinca Inst Nucl Sci, Mike Petrovioa Alasa 12-14, Belgrade 11001, Serbia

[2] Coll Appl Sci Tech Studies & Technol, Kosanciceva 36, Krusevac 37000, Serbia

[3] Inst Med Plant Res Dr Josif Pancic, Tadeusa Koscuska 1, Belgrade 11000, Serbia

来源：

RECORDS OF NATURAL PRODUCTS | 2020年 / 14卷 / 05期

关键词：

Punica granatum L; peel extract; phenolic compounds; cytotoxicity; cancer cells; IN-VITRO; ANTIOXIDANT ACTIVITIES; ELLAGIC ACID; METASTASIS; APOPTOSIS; FRUIT; JUICE; PROLIFERATION; ELLAGITANNINS; PLANTS;

D O I：

10.25135/rnp.170.19.11.1477

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The aim of the present study was to investigate effects of pomegranate peel (PP) extract on different human cancer cell lines. MTT was performed to estimate cytotoxic effects of PP extract against HTB140, HTB177, MCF7, HCT116 human cancer cell lines and MRC-5 normal fibroblasts. Clonogenic assay was used to reveal cell survival after the treatment with PP extract. Cell cycle analysis was done using flow cytometry. Wound healing assay was applied to estimate inhibitory effects of PP extract on migration of cancer cells. The results showed that PP extract expressed selective cytotoxicity for cancer cells compared to normal cell line. Analyzed cancer cell lines displayed individual variations in sensitivity to PP extract reflected through changes in clonogenic survival, cell cycle distribution and migration, which may be due to the specific nature of each tested cell line. In conclusion, PP extract exhibits good inhibitory effects on tested cancer cell lines.

引用

页码：326 / 339

页数：14

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