Emergence of Oseltamivir-Resistant Pandemic H1N1 in an Immunocompetent Child with Severe Status Asthmaticus

被引：2
作者：
Renaud, Christian [1 ,2 ,3 ]
Kuypers, Jane
Aspesberro, Francois [3 ]
Rosenfeld, Margaret [3 ]
Englund, Janet A. [3 ]
机构：
[1] Univ Washington, Med Ctr, Dept Lab Med, Mol Virol Lab, Seattle, WA 98102 USA
[2] Fred Hutchinson Canc Res Ctr, Div Infect Dis, Seattle, WA 98104 USA
[3] Univ Washington, Seattle Childrens Hosp, Dept Pediat, Seattle, WA 98102 USA
来源：
JOURNAL OF ASTHMA | 2011年 / 48卷 / 06期
关键词：
children; chronic lung disease; drug resistance; influenza; neuraminidase inhibitor; INFLUENZA-A; INFECTION; VIRUS;
D O I：
10.3109/02770903.2011.582660
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Introduction. Pandemic influenza A (H1N1) may cause severe illness in pediatric patient with chronic lung disease. Case Report. We describe the emergence of oseltamivir resistance in an immunocompetent child with status asthmaticus triggered by pandemic influenza A (H1N1). This case highlights the possible relationship between influenza viral load and risk of resistance emergence in children with asthma. Influenza vaccination should continue to be emphasized as the mainstay of prevention in children with chronic lung disease. Conclusion. Influenza virus can lead to severe status asthmaticus and can develop oseltamivir resistance in immunocompetent children.</.
引用
收藏
页码：572 / 575
页数：4
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