Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice

被引：18

作者：

Iwai, Takashi ^{[1
,2
,3
]}

Jin, Kazushi ^{[1
]}

Ohnuki, Tomoko ^{[1
]}

Sasaki-Hamada, Sachie ^{[1
]}

Nakamura, Minami ^{[3
]}

Saitoh, Akiyoshi ^{[1
,2
]}

Sugiyama, Azusa ^{[1
,2
]}

Ikeda, Masaatsu ^{[1
]}

Tanabe, Mitsuo ^{[3
]}

Oka, Jun-Ichiro ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Pharmacol Lab, Noda, Chiba 2788510, Japan

[2] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Neuropsychopharmacol, Tokyo 1878553, Japan

[3] Kitasato Univ, Sch Pharm, Dept Pharmacol, Minato Ku, Tokyo 1088641, Japan

来源：

NEUROPEPTIDES | 2015年 / 49卷

关键词：

Glucagon-like peptide-2; Y-maze; Elevated plus-maze; Antidepressant; Anxiety; Major depression; Serotonin; ACTH; ANTIINFLAMMATORY ACTIONS; CELL-DEATH; RECEPTOR; IMPAIRMENT; RATS; INFLAMMATION; METAANALYSIS; DISORDERS; CYTOKINES; PATHWAYS;

D O I：

10.1016/j.npep.2014.11.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effectiveness of glucagon-like peptide-2 (GLP-2) on memory impairment in lipopolysaccharide (LPS)-treated mice, and anxiety-like behavior in adrenocorticotropic hormone (ACTH)treated mice. In the Y-maze test, LPS (10 mu g/mouse, i.c.v.) significantly decreased spontaneous alternation, which was prevented by pretreatment with GLP-2 (0.01-0.3 mu g/mouse, i.c.v.). The GLP-2 treatment just before the Y-maze test also improved LPS-induced memory impairment. Continuous treatment with GLP-2 (3 mu g/mouse, i.c.v.) had no effect on the open-field test in saline-treated or ACTH-treated mice. Chronic ACTH treatment did not cause anxiogenic effects in the elevated plus-maze test. GLP-2 showed weak anxiolytic-like effects in the elevated plus-maze test in ACTH-treated, but not saline-treated mice. Moreover, GLP-2 increased 5-HT, but not 5-HIAA and tryptophan hydroxylase 2 levels in the amygdala of ACTH-treated mice. Pharmacological depletion of 5-HT prevented the anxiolytic effects of GLP-2. These results suggest that GLP-2 protected and improved memory function in LPS-treated mice, and also had anxiolytic effects due to changes in the 5-HT system. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：7 / 14

页数：8

共 46 条

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