Management of pregnancy in paroxysmal nocturnal hemoglobinuria on long-term eculizumab

被引：11

作者：

Vekemans, Marie-Christiane ^{[1
]}

Lambert, Catherine ^{[1
]}

Ferrant, Augustin ^{[1
]}

Saussoy, Pascale ^{[2
]}

Havelange, Violaine ^{[1
]}

Debieve, Frederic ^{[3
]}

Van den Neste, Eric ^{[1
]}

Michaux, Lucienne ^{[1
]}

机构：

[1] Catholic Univ Louvain, Clin Univ St Luc, Dept Hematol, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Clin Univ St Luc, Dept Biol Clin, B-1200 Brussels, Belgium

[3] Catholic Univ Louvain, Clin Univ St Luc, Dept Obstet, B-1200 Brussels, Belgium

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2015年 / 26卷 / 04期

关键词：

eculizumab; paroxysmal nocturnal hemoglobinuria; pregnancy; thrombosis; COMPLEMENT INHIBITOR ECULIZUMAB; NATURAL-HISTORY; THROMBOSIS; PNH;

D O I：

10.1097/MBC.0000000000000248

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pregnancy in women with paroxysmal nocturnal hemoglobinuria (PNH) is associated with increased maternal and fetal complications, to such an extent that PNH has for long been considered a relative contraindication for pregnancy. The most serious life-threatening complications are venous thromboembolic events, the risk of which is increased by the hypercoagulable state related to pregnancy. Eculizumab, a C5 complement inhibitor, has revolutionized the treatment of PNH. However, there are no published trials evaluating its use in pregnancy. Most recommendations are based on expert opinions and case reports. We report on the favorable outcome of a PNH patient who became pregnant while under eculizumab, suggesting that this drug can be given from conception to delivery. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：464 / 466

页数：3

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