11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Subjects With Type 2 Diabetes Mellitus

被引：14
作者：
Li, Xia [1 ]
Wang, Jingli [2 ]
Yang, Qin [3 ]
Shao, Shiying [4 ]
机构：
[1] Three Gorges Univ, Peoples Hosp, Peoples Hosp Yichang 1, Div Endocrinol, Yichang, Peoples R China
[2] Jingzhou Cent Hosp, Div Endocrinol, Jingzhou, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Hosp, Div Pathol, Jiefang Rd 1095, Wuhan 430030, Hubei, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Hosp, Div Endocrinol, Wuhan, Hubei, Peoples R China
来源：
AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 2017年 / 354卷 / 04期
基金：
中国国家自然科学基金;
关键词：
11 beta-Hydroxysteroid dehydrogenase type 1; Obesity; Type 2 diabetes mellitus; Insulin resistance; INSULIN-RECEPTOR SUBSTRATE-1; SUBCUTANEOUS ADIPOSE-TISSUE; 11-BETA-HSD1; INHIBITION; SELECTIVE-INHIBITION; CORTISOL METABOLISM; GLUCOSE-TOLERANCE; PANCREATIC-ISLETS; BI; 135585; MICE; RESISTANCE;
D O I：
10.1016/j.amjms.2017.03.023
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity is one of the most significant contributors to the development of type 2 diabetes mellitus. Tissue-specific glucocorticoids regulated by 11 beta-hydroxysteroid dehydrogenase enzyme (11 beta-HSD) type 1 are involved in central obesity and obesity-related comorbidities. Moderate downregulation of 11 beta-HSD1 can attenuate insulin insensitivity and the impairment of glucose-stimulated insulin secretion. Some of the beneficial effects of 11 beta-HSD1 inhibition may be mediated, at least in part, through inactivation of tissue-specific glucocorticoid action related to insulin signaling mechanisms, alleviation of abnormal cytokine profile and the improvement of beta-cell function. Thus, 11 beta-HSD1 is a promising target for the treatment and prevention of type 2 diabetes mellitus with obesity.
引用
收藏
页码：408 / 414
页数：7
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