Chromatin-based Mechanisms of Renal Epithelial Differentiation

被引：7

作者：

Surendran, Kameswaran ^{[1
]}

Kopan, Raphael ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2011年 / 22卷 / 07期

关键词：

NEPHRON PROGENITOR POPULATION; GENE-EXPRESSION; KIDNEY DEVELOPMENT; INTERMEDIATE MESODERM; EPIGENETIC REGULATION; METANEPHRIC KIDNEY; MAMMALIAN KIDNEY; MOUSE KIDNEY; CELLS; NOTCH;

D O I：

10.1681/ASN.2010101018

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Successful regenerative renal medicine depends on understanding the molecular mechanisms by which diverse phenotypes of epithelial cells differentiate from metanephric mesenchyme to populate nephrons. Whereas many genes are maintained in a poised state within the population of pluripotent progenitors, specialized epithelial functions reflect the selective expression of a subset of genes and the repression of all others. Here we highlight some common mechanisms of cell differentiation and epigenetic regulation to discuss their implications for renal epithelial development, repair, and disease.

引用

页码：1208 / 1212

页数：5

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