Influence of immune aging on vaccine responses

INFORMATION FOR CATEGORY 1 CME CREDIT Credit can now be obtained, free for a limited time, by reading the review articles in this issue. Please note the following instructions. Method of Physician Participationin Learning Process: Thecorematerial for these activities can be read in this issue of the Journal or online at the JACI Web site: www.jacionline.org. The accompanying tests may only be submitted online at www.jacionline.org. Fax or other copies will not be accepted. Date of Original Release: May 2020. Credit may be obtained for these courses until April 30, 2021. Copyright Statement: Copyright (C) 2020-2021. All rights reserved. Overall Purpose/Goal: To provide excellent reviews on key aspects of allergic disease to those who research, treat, or manage allergic disease. Target Audience: Physicians and researchers within the field of allergic disease. Accreditation/Provider Statements and Credit Designation: The AmericanAcademy ofAllergy, Asthma& Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuingmedical education for physicians. TheAAAAI designates this journal-based CME activity for a maximumof 1.00AMA PRACategory 1 Credit (TM). Physicians should claim only the credit commensurate with the extent of their participation in the activity. List of Design Committee Members: Claire E. Gustafson, PhD, Chulwoo Kim, PhD, Cornelia M. Weyand, MD, PhD, and J_org J. Goronzy, MD, PhD (authors); Zuhair K. Ballas, MD (editor) Disclosure of Significant Relationships with Relevant Commercial Companies/Organizations: The authors declare that they have no relevant conflicts of interest. Z. K. Ballas (editor) disclosed no relevant financial relationships. Activity Objectives: 1. To understand the differences in vaccine responses based on age and how older adults respond to various types of vaccines. 2. To understand age-related defects in T cells and how that affects primary vaccine response. 3. To discuss ways in which aging affects the functionality of the B-cell compartment. 4. To understand different vaccination strategies that can be used to overcome deficiencies of vaccine responses in the aging immune system.