A diagnostic approach to mild bleeding disorders

被引：57
作者：
Boender, J. [1 ]
Kruip, M. J. H. A. [1 ]
Leebeek, F. W. G. [1 ]
机构：
[1] Erasmus Univ, Dept Hematol, Med Ctr, Rotterdam, Netherlands
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2016年 / 14卷 / 08期
关键词：
bleeding disorder; bleeding score; blood coagulation disorders; diagnosis; DNA sequencing; hemostasis; VON-WILLEBRAND-DISEASE; LIGHT TRANSMISSION AGGREGOMETRY; ABO BLOOD-GROUP; PLATELET-FUNCTION; ASSESSMENT-TOOL; HEMOPHILIA-A; ONE-STAGE; QUESTIONNAIRE; DEFICIENCY; MANAGEMENT;
D O I：
10.1111/jth.13368
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mild inherited bleeding disorders are relatively common in the general population. Despite recent advances in diagnostic approaches, mild inherited bleeding disorders still pose a significant diagnostic challenge. Hemorrhagic diathesis can be caused by disorders in primary hemostasis (von Willebrand disease, inherited platelet function disorders), secondary hemostasis (hemophilia A and B, other (rare) coagulant factor deficiencies) and fibrinolysis, and in connective tissue or vascular formation. This review summarizes the currently available diagnostic methods for mild bleeding disorders and their pitfalls, from structured patient history to highly specialized laboratory diagnosis. A comprehensive framework for a diagnostic approach to mild inherited bleeding disorders is proposed.
引用
收藏
页码：1507 / 1516
页数：10
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