Structurally Rigid 9-Amino-benzo[c]cinnoliniums Make Up a Class of Compact and Large Stokes-Shift Fluorescent Dyes for Cell-Based Imaging Applications

被引：48

作者：

Shen, Yanming ^{[2
]}

Shang, Zhihao ^{[2
]}

Yang, Yanhong ^{[3
]}

Zhu, Shaojia ^{[1
]}

Qian, Xuhong ^{[1
,2
]}

Shi, Ping ^{[1
]}

Zheng, Jing ^{[3
]}

Yang, Youjun ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 11期

基金：

中国国家自然科学基金;

关键词：

MULTICOLOR FLOW-CYTOMETRY; ENERGY-TRANSFER CASSETTES; FLUOROGENIC DYES; FLUOROPHORES; PROTEIN; PROBE; CONSTRUCTION; EXPRESSION; BIOSENSORS; BODIPY;

D O I：

10.1021/acs.joc.5b00242

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Classic fluorescent dyes, such as coumarin, naphthalimide, fluorescein, BODIPY, rhodamine, and cyanines, are cornerstones of various spectroscopic and microscopic methods, which hold a prominent position in biological studies. We recently found that 9-amino-benzo[c]cinnoliniums make up a novel group of fluorophores that can be used in biological studies. They are featured with a succinct conjugative push-pull backbone, a broad absorption band, and a large Stokes shift. They are potentially useful as a small-molecule alternative to R-phycoerythrin to pair with fluorescein in multiplexing applications.

引用

页码：5906 / 5911

页数：6

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