Nasal Nitric Oxide and Nasal Cytology as Predictive Markers of Short-Term Sublingual Allergen-Specific Immunotherapy Efficacy in Children with Allergic Rhinitis

被引:13
作者
Parisi, Giuseppe Fabio [1 ]
Manti, Sara [1 ]
Papale, Maria [1 ]
Amato, Melania [1 ]
Licari, Amelia [2 ]
Marseglia, Gian Luigi [2 ]
Leonardi, Salvatore [1 ]
机构
[1] Univ Catania, Catania, Italy
[2] Univ Pavia, Pavia, Italy
关键词
allergy; immunotherapy; SLIT; children; nitric oxide; NO; nasal cytology; VAS; rhinitis; house dust mites; DISEASES; ANTIHISTAMINES; BIOMARKERS;
D O I
10.1177/19458924211060592
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background Few studies have been conducted on the short-term response to sublingual immunotherapy (SLIT). Objective The purpose of our experimental trial was to evaluate if two markers such as nasal nitric oxide (nNO) and nasal cytology could be useful to identify a precocious clinical efficacy of SLIT treatment. Methods We enrolled 34 children aged 6 to 14 years old with diagnosis of allergic rhinitis (AR) and documented sensitization towards house dust mites. We started allergoid-monomeric tablets immunotherapy along with any conventional therapy for AR and we evaluated at baseline (T0), after one (T1), two (T2), three (T3), and six months (T6) the effects of the treatment through the study of: i) a visual analogue scale (VAS 1-10); ii) measurement of nNO; iii) measurement of FeNO; iv) nasal cytology; v) spirometry; and vi) evaluation of any conventional therapy. Results We observed an improvement in symptoms evaluated by global VAS (T0 vs. T6: 47.13 vs. 17.57; p < .05) and a statistically significant reduction of nNO (1035.2 +/- 956.08 vs. 139.2 +/- 59.01; p < .05). In this case, significance was reached when the patients completed the 6 months of treatment. Cytological evaluation revealed significant reduction in nasal eosinophils (T0 vs. T6: 87% vs. 16%; p < .01). Moreover, at T0, 56% of patients had also neutrophils that were reduced up to the 8% at T6 (p < .05). Conclusions Our data confirm the effectiveness of SLIT treatment from a clinical perspective and identifies two biomarkers, such as nNO and nasal cytology, as predictive of treatment efficacy in the short term.
引用
收藏
页码:323 / 329
页数:7
相关论文
共 29 条
[11]   Nasal nitric oxide in upper airways in children with asthma and allergic rhinitis [J].
Galiniak, Sabina ;
Biesiadecki, Marek ;
Aebisher, David ;
Rachel, Marta .
ADVANCES IN MEDICAL SCIENCES, 2020, 65 (01) :127-133
[12]   Nasal cytology can predict clinical efficacy of subcutaneous immunotherapy in intermittent allergic rhinitis [J].
Jura-Szoltys, Edyta ;
Gawlik, Radoslaw ;
Branicka, Olga ;
Stryjewska-Makuch, Grazyna ;
Gluck, Joanna .
POSTEPY DERMATOLOGII I ALERGOLOGII, 2022, 39 (06) :1110-1115
[13]   Allergen-specific immunotherapy for allergic rhinitis: A new insight into its clinical efficacy and mechanism [J].
Ohashi, Y ;
Nakai, Y ;
Tanaka, A ;
Kakinoki, Y ;
Washio, Y ;
Nakai, Y .
ACTA OTO-LARYNGOLOGICA, 1998, :178-190
[14]   Nasal nitric oxide does not control basal nasal patency or acute congestion following allergen challenge in allergic rhinitis [J].
Silkoff, PE ;
Roth, Y ;
McClean, P ;
Cole, P ;
Chapnik, J ;
Zamel, N .
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1999, 108 (04) :368-372
[15]   Increased Expression of miR-146a in Children With Allergic Rhinitis After Allergen-Specific Immunotherapy [J].
Luo, Xi ;
Hong, Haiyu ;
Tang, Jun ;
Wu, Xingmei ;
Lin, Zhibin ;
Ma, Renqiang ;
Fan, Yunping ;
Xu, Geng ;
Liu, Dabo ;
Li, Huabin .
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2016, 8 (02) :132-140
[16]   Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis [J].
Sahin, E. ;
Dizdar, D. ;
Dinc, M. E. ;
Cirik, A. A. .
JOURNAL OF LARYNGOLOGY AND OTOLOGY, 2017, 131 (11) :997-1001
[17]   The Evaluation Value of the Modified Lund-Kennedy Nasal Endoscopy Score on the Efficacy of Sublingual Immunotherapy for Allergic Rhinitis [J].
Zhang, Yinglong ;
Jiang, Hong ;
Long, Yu ;
Li, Jie .
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 2024, 38 (06) :366-372
[18]   Clinical application of fractional exhaled nitric oxide and nasal nitric oxide levels for the assess eosinophilic inflammation of allergic rhinitis among children [J].
Luo, Jia-Ying ;
Chen, Hui-An ;
Ma, Jing ;
Xiao, Yong-Xin ;
Yao, Jing-Jiong ;
Liang, Jia-Min ;
Du, Ying-Si ;
Wang, Feng ;
Sun, Bao-Qing .
TRANSLATIONAL PEDIATRICS, 2021, 10 (04) :746-753
[19]   Effects of sublingual-specific immunotherapy on pulmonary function and exhaled nitric oxide levels in asthmatic children with and without allergic rhinitis [J].
Ai, Tao ;
Wang, Li ;
Luo, Ronghua ;
Fan, Yinghong ;
Liao, Huiling ;
Xia, Wanmin ;
Zhang, Lei ;
Duan, Yaping .
TRANSLATIONAL PEDIATRICS, 2020, 9 (05) :686-694
[20]   Increased Nasal Blimp1+Treg Cells After Sublingual Immunotherapy Reflect the Efficacy of Treatment in Allergic Rhinitis [J].
Pan, Yue ;
Zhang, Xinxin ;
Geng, Huanting ;
Yu, Yan ;
Liu, Jianyong ;
Li, Menglin ;
Yang, Huijun ;
Yuan, Yifang ;
Xu, Yao ;
Wu, Yujia ;
Wu, Geping ;
Ma, Xingkai ;
Cheng, Lei .
ADVANCES IN THERAPY, 2024, 41 (04) :1698-1710