Presentation of BMP-2 from a Soft Biopolymeric Film Unveils its Activity on Cell Adhesion and Migration

被引：117
作者：
Crouzier, Thomas [1 ]
Fourel, Laure [1 ]
Boudou, Thomas [1 ]
Albiges-Rizo, Corinne [2 ]
Picart, Catherine [1 ]
机构：
[1] CNRS INPG, LMGP, F-38016 Grenoble, France
[2] Univ Grenoble 1, Inst Albert Bonniot, INSERM U823, ERL CNRS3148, F-38042 Grenoble 9, France
来源：
ADVANCED MATERIALS | 2011年 / 23卷 / 12期
关键词：
BONE MORPHOGENETIC PROTEIN-2; EXTRACELLULAR-MATRIX; GROWTH-FACTORS; OSTEOBLAST LINEAGE; DIFFERENTIATION; INTEGRINS; MICROENVIRONMENTS; BIOMATERIALS; DELIVERY; ACTIVATION;
D O I：
10.1002/adma.201004637
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The dramatic effect of morphogenetic protein 2 (BMP-2), presented to cells in a "matrix bound" manner is described. BMP-2 is either delivered in solution or bound to a thin film made of poly(lysine) and hyaluronan. In this later case only, a striking effect of BMP-2 on cell adhesion and migration is observed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：H111 / H118
页数：8
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