Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp isolated from Hydnocarpus anthelminthicus

被引：38

作者：

Prachya, Surasak

Wiyakrutta, Suthep

Sriubolmas, Nongluksna

Ngamrojanavanich, Nattaya

Mahidol, Chulabhorn

Ruchirawat, Somsak

Kittakoop, Prasat

机构：

[1] Chulabhorn Res Inst, Bangkok 10210, Thailand

[2] Chulabhorn Grad Inst, Bangkok 10210, Thailand

[3] Chulalongkorn Univ, Fac Sci, Program Biotechnol, Bangkok, Thailand

[4] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand

[5] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Microbiol, Bangkok, Thailand

[6] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok, Thailand

[7] Mahidol Univ, Inst Sci & Technol Res & Dev, Chulabhorn Res Ctr, Bangkok 10700, Thailand

来源：

PLANTA MEDICA | 2007年 / 73卷 / 13期

关键词：

D O I：

10.1055/s-2007-990240

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Mycoepoxydiene (1) and derivatives, deacetylmycoepoxydiene (2) and 2,3-dihydromycoepoxydiene (3), were isolated from a broth extract of the endophytic fungus, Phomopsis sp., which was isolated from a Thai medicinal plant, Hydnocarpus anthelminthicus. Compounds 1 and 2 exhibited potent cytotoxic activity, while a dihydro derivative 3 was inactive. The present work suggests that the alpha,beta-unsaturated lactone moiety in mycoepoxydienes might be responsible for the cytotoxicity.

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页码：1418 / 1420

页数：3

相关论文

共 13 条

[1] Mycoepoxydiene represents a novel class of fungal metabolites [J].

Cai, P ;

McPhail, AT ;

Krainer, E ;

Katz, B ;

Pearce, C ;

Boros, C ;

Caceres, B ;

Smith, D ;

Houck, DR .

TETRAHEDRON LETTERS, 1999, 40 (08) :1479-1482

[2] Endophyte fungal isolates from Podophyllum peltatum produce podophyllotoxin [J].

Eyberger, Amy L. ;

Dondapati, Rajeswari ;

Porter, John R. .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (08) :1121-1124

[3] Cytotoxic and antimicrobial metabolites from marine lignicolous fungi, Diaporthe sp. [J].

Lin, X ;

Huang, YJ ;

Fang, MJ ;

Wang, JF ;

Zheng, ZH ;

Su, WJ .

FEMS MICROBIOLOGY LETTERS, 2005, 251 (01) :53-58

[4] KADSULIGNANS-L-N, 3 DIBENZOCYCLOOCTADIENE LIGNANS FROM KADSURA-COCCINEA [J].

LIU, JS ;

LI, L .

PHYTOCHEMISTRY, 1995, 38 (01) :241-245

[5] Endophytic fungal metabolite fumigaclavine C causes relaxation of isolated rat aortic rings [J].

Ma, HY ;

Song, YC ;

Mao, YY ;

Jiang, JH ;

Tan, RX ;

Luo, L .

PLANTA MEDICA, 2006, 72 (05) :387-392

[6]

Shen Y., 2007, Chinese Patent, Patent No. [CN1903858 A 20070131, 1903858, CN 1903858 A 20070131]

[7] Anthracobic acids A and B, two polyketides, produced by an endophytic fungus Anthracobia sp. [J].

Shiono, Y .

CHEMISTRY & BIODIVERSITY, 2006, 3 (02) :217-223

[8] Evidence for paclitaxel from three new endophytic fungi of Himalayan Yew of Nepal [J].

Shrestha, K ;

Strobel, GA ;

Shrivastava, SP ;

Gewali, MB .

PLANTA MEDICA, 2001, 67 (04) :374-376

[9] ISOLATION AND X-RAY STRUCTURE DETERMINATION OF A NEOLIGNAN FROM CLERODENDRON-INERME SEEDS [J].

SPENCER, GF ;

FLIPPENANDERSON, JL .

PHYTOCHEMISTRY, 1981, 20 (12) :2757-2759

[10] Asymmetric total syntheses of (+)-mycoepoxydiene and related natural product (-)-1893A: Application of one-pot ring-opening/cross/ring-closing metathesis to construct their 9-oxabicyclo[4.2.1]nona-2,4-diene skeleton [J].

Takao, K ;

Yasui, H ;

Yamamoto, S ;

Sasaki, D ;

Kawasaki, S ;

Watanabe, G ;

Tadano, K .

JOURNAL OF ORGANIC CHEMISTRY, 2004, 69 (25) :8789-8795