HLA-G in B-chronic lymphocytic leukaemia:: Clinical relevance and functional implications

被引：27

作者：

Rebmann, Vera ^{[1
]}

Nueckel, Holger ^{[2
]}

Duehrsen, Ulrich ^{[2
]}

Grosse-Wilde, Hans ^{[1
]}

机构：

[1] Univ Klinikum Essen, Inst Immunol, D-45122 Essen, Germany

[2] Univ Klinikum Essen, Zentrum Innere Med, Abt Hamatol, Essen, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2007年 / 17卷 / 06期

关键词：

HLA-G; sHLA-G; B-CLL; immune escape mechanism;

D O I：

10.1016/j.semcancer.2007.06.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

HLA-G appears to be involved in regulatory functions counteracting the cellular immune response of T and NK cells by several pathways. We here summarize the HLA-G expression patterns in leukaemia with emphasis on the clinical relevance of this expression for disease progression. Especially in patients with B-chronic lymphocytic leukaemia (B-CLL) the HLA-G expression on B-CLL cells was strongly associated with a reduced treatment-free survival. The corresponding immunological parameters point to a broad immunosuppression in these patients. Thus, HLA-G seems to contribute to the impaired immune response in B-CLL supporting disease progression. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：430 / 435

页数：6

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