Injectable thiol-Epoxy "Click" Hydrogels

被引：18
|
作者：
Gao, Lilong [1 ]
Li, Xiaojun [2 ]
Wang, Ying [1 ,2 ]
Zhu, Weipu [1 ,3 ]
Shen, Zhiquan [1 ]
Li, Xiaodong [2 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE, Key Lab Macromolecular Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Stomatol Hosp, Hangzhou 310006, Zhejiang, Peoples R China
[3] Key Lab Adsorpt & Separat Mat & Technol Zhejiang, Hangzhou 310027, Zhejiang, Peoples R China
来源：
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2016年 / 54卷 / 17期
基金：
中国国家自然科学基金;
关键词：
biocompatibility; click reaction; injectable hydrogel; thiol-epoxy reaction; radical polymerization; CROSS-LINKING; MULTIFUNCTIONAL POLYMERS; DRUG-RELEASE; COPOLYMERS; MICELLES; STRATEGY;
D O I：
10.1002/pola.28156
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A novel crosslinking strategy for injectable "click" hydrogels is reported. Precursors containing thiol or epoxy groups are facilely synthesized by polycondensation and radical polymerization respectively, which are used to in situ form hydrogels under physiological conditions within tens of seconds via thiol-epoxy reaction. The suitable gelation time and low cytotoxicity of this kind of hydrogels make it a potential candidate as implanted material for biomedical applications.
引用
收藏
页码：2651 / 2655
页数：5
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