Humoral immunity 5 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine

被引：36
作者：
Barreto, L.
Guasparini, R.
Meekison, W.
Noya, F.
Young, L.
Mills, E.
机构：
[1] Sanofi Pasteur Ltd, Toronto, ON M2R 3T4, Canada
[2] Fraser Hlth Authority, Surrey, BC V3X 3A4, Canada
[3] Westcoast Clin Res, Coquitlam, BC V3C 4J2, Canada
[4] Montreal Childrens Hosp, Div Infect Dis, Montreal, PQ H3H 1P3, Canada
来源：
VACCINE | 2007年 / 25卷 / 48期
关键词：
pertussis; vaccine; serology;
D O I：
10.1016/j.vaccine.2007.09.031
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Persistence of antibodies following a single dose of Tdap, vaccine (tetanus, diphtheria, and five-component acellular pertussis vaccine for use in individuals past childhood) was evaluated in a follow-up of adolescents (N = 324) and adults (N = 644) who had received Tdap in earlier clinical trials. Outcome measures were seroprotection (tetanus and diphtheria) or seropositivity (pertussis) and geometric mean titers. Humoral immune responses to all antigens were robust 1 month after initial immunization; antibodies exceeded pre-immunization levels 1, 3, and 5 years later. These data will contribute to selecting the optimal interval for booster doses of Tdap. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：8172 / 8179
页数：8
相关论文
共 26 条
  • [1] Infant pertussis - Who was the source?
    Bisgard, KM
    Pascual, FB
    Ehresmann, KR
    Miller, CA
    Cianfrini, C
    Jennings, CE
    Rebmann, CA
    Gabel, J
    Schauer, SL
    Lett, SM
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2004, 23 (11) : 985 - 989
  • [2] Recommendations are needed for adolescent and adult pertussis immunisation:: rationale and strategies for consideration
    Campins-Martí, M
    Cheng, HK
    Forsyth, K
    Guiso, N
    Halperin, S
    Huang, LM
    Mertsola, J
    Oselka, G
    Ward, J
    von König, CHW
    Zepp, F
    [J]. VACCINE, 2001, 20 (5-6) : 641 - 646
  • [3] *CDC, 2006, MMWR-MORBID MORTAL W, V55, P21
  • [4] *CDC, 2006, MMWR-MORBID MORTAL W, V55, P22
  • [5] Centers for Disease Control and Prevention, 2005, MMWR-MORBID MORTAL W, V54, P12
  • [6] The epidemiology of pertussis:: A comparison of the epidemiology of the disease pertussis with the epidemiology of Bordetella pertussis infection
    Cherry, JD
    [J]. PEDIATRICS, 2005, 115 (05) : 1422 - 1427
  • [7] The science and fiction of the "resurgence" of pertussis
    Cherry, JD
    [J]. PEDIATRICS, 2003, 112 (02) : 405 - 406
  • [8] A search for serologic correlates of immunity to Bordetella pertussis cough illnesses
    Cherry, JD
    Gornbein, J
    Heininger, U
    Stehr, K
    [J]. VACCINE, 1998, 16 (20) : 1901 - 1906
  • [9] Immunity to pertussis 5 years after booster immunization during adolescence
    Edelman, Kati
    He, Qiushui
    Makinen, Johanna
    Sahlberg, Anna
    Haanpera, Marjo
    Schuerman, Lode
    Wolter, Joanne
    Mertsola, Jussi
    [J]. CLINICAL INFECTIOUS DISEASES, 2007, 44 (10) : 1271 - 1277
  • [10] Pertussis-specific cell-mediated and humoral immunity in adolescents 3 years after booster immunization with acellular pertussis vaccine
    Edelman, KJ
    He, QS
    Makinen, JP
    Haanpera, MS
    Minh, NNT
    Schuerman, L
    Wolter, J
    Mertsola, JA
    [J]. CLINICAL INFECTIOUS DISEASES, 2004, 39 (02) : 179 - 185
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