Continuous intravenous infusion of ghrelin does not stimulate feeding in tumor-bearing rats

被引：14

作者：

Chance, William T. ^{[1
,2
]}

Dayal, Ramesh ^{[2
]}

Friend, Lou Ann ^{[1
]}

Thomas, Ingrid ^{[1
]}

Sheriff, Sulaiman ^{[1
]}

机构：

[1] Univ Cincinnati, Med Ctr, Dept Surg, Cincinnati, OH 45267 USA

[2] Vet Affairs Med Ctr, Res Serv, Cincinnati, OH 45267 USA

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2008年 / 60卷 / 01期

关键词：

D O I：

10.1080/01635580701753016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The development of anorexia continues to be a serious treatment issue for cancer patients. Because the orexigenic peptide, ghrelin, is active through systemic routes and activates hypothalamic neuropeptide systems known to be refractory in anorectic tumor-bearing (TB) rats, we investigated whether it would prevent the development of cancer anorexia when infused continuously intravenously. The 24-h food intake was increased in nontumor-bearing (NTB) rats at a dose of 288 ug/day ghrelin. However, no tested dose of ghrelin, up to 576 ug/day, elicited increased feeding in TB rats prior to or subsequent to the development of anorexia. In hypothalamus, ghrelin-infused TB rats exhibited significantly increased concentration of neuropeptide Y (NPY) as compared to saline-infused TB rats. Hypothalamic expression of NPY and agouti-related protein (AgRP) messenger RNA were elevated in ghrelin-infused TB rats as compared to NTB rats, but saline-infused TB rats also exhibited increased expression of AgRP. Proopiomelanocortin message was reduced in ghrelin-infused and saline-infused TB rats as compared to noninfused TB control rats. Although ghrelin infusion did not preserve muscle protein, a significant saving in body fat was observed in TB rats. Thus, the adiposity effects of ghrelin did not require an orexigenic response to the peptide. These results suggest that continuous ghrelin infusion may not be an effective treatment for cancer anorexia.

引用

页码：75 / 90

页数：16

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