Identification of key candidate genes for wing length-related traits by whole-genome resequencing in 772 geese

被引:1
|
作者
Ouyang, J. [1 ]
Wu, Y. [1 ]
Li, Y. [1 ]
Miao, J. [1 ]
Zheng, S. [1 ]
Tang, H. [1 ]
Wang, C. [1 ]
Xiong, Y. [1 ]
Gao, Y. [1 ]
Wang, L. [1 ]
Yan, X. [1 ]
Chen, H. [1 ]
机构
[1] Jiangxi Sci & Technol Normal Univ, Sch Life Sci, Nanchang, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Goose; wing length; RBM47; whole genome resequencing; GWAS; SINGLE NUCLEOTIDE POLYMORPHISMS; ASSOCIATION; POPULATION; SEQUENCE; RBM47; TOOL;
D O I
10.1080/00071668.2022.2102889
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
1. A total of 772, 420-day-old Xingguo grey geese (XGG) were sequenced using a low-depth (similar to 1 x) whole-genome resequencing strategy to reveal the genetic mechanism of wing length-related traits by genome-wide association analysis (GWAS). 2. The results showed that 119 SNPs had genome-wide significance for wing length in five regions of chromosome 4, of which the most significant locus (P = 7.95E-11) was located upstream of RBM47 and explained 7.3% of the phenotypic variation. 3. A total of 219 SNPs located on chromosome 4 were associated with 2-joint-wing length, of which four SNPs reached the genome-wide significant level. However, for the length of 1-joint-wing and primary feather, we did not detect any associated locus. 4. Six promising candidate genes, R8M47, SLAIN2, GRXCR1, SLC10A4, APBB2 and NSUN7 on chromosome 4, may play an important role in the growth and development of feathers, muscles and bones.
引用
收藏
页码:747 / 753
页数:7
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