Graphene assisted terahertz metamaterials for sensitive bio-sensing

被引：101

作者：

Lee, Sang-Hun ^{[1
]}

Choe, Jong-Ho ^{[2
]}

Kim, Chulki ^{[1
]}

Bae, Sukang ^{[3
]}

Kim, Jin-Soo ^{[2
]}

Park, Q-Han ^{[2
]}

Seo, Minah ^{[1
,4
]}

机构：

[1] Korea Inst Sci & Technol, Sensor Syst Res Ctr, Seoul 02792, South Korea

[2] Korea Univ, Dept Phys, Seoul 02841, South Korea

[3] Korea Inst Sci & Technol, Appl Quantum Composites Res Ctr, Jeollabuk Do 55324, South Korea

[4] Korea Univ Sci & Technol UST, KIST Sch, Div Nano & Informat Technol, Seoul 02792, South Korea

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2020年 / 310卷

基金：

新加坡国家研究基金会;

关键词：

Metamaterial; Terahertz; Biosensor; Graphene; INFRARED-SPECTROSCOPY; DNA; MOLECULES; ABSORPTION; TRANSISTOR; NANOSCALE;

D O I：

10.1016/j.snb.2020.127841

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report that single-stranded deoxyribonucleic acids (ssDNAs) at very low concentrations can be detected using graphene-combined nano-slot-based terahertz (THz) resonance. A combination of the resonant structure and tuned electro-optical properties of graphene can provide unprecedentedly sensitive biomolecule sensing even using very low energy THz photons, overcoming the huge scale difference of 10,000:1 between the wavelength and the size of the ssDNAs. Ultrahigh sensitivity is obtained by the significant increase in the absorption cross-section of the graphene sheet with the targeted biomolecules, induced by strong THz field enhancement at the resonance frequency inside the slots. Clearly distinguishable THz optical signals were observed between different species of ssDNAs even at the nano-mole level and analyzed quantitatively in terms of the electro-optical properties of the suspended graphene layer modified by the attached ssDNAs without any molecular-specific labeling for the THz regime. Quantitative analysis of ssDNA molecule adsorption was carried based on the change in conductivity using a theoretical THz transmission model.

引用

页数：7

共 51 条

[1] Competing Interactions in DNA Assembly on Graphene [J].

Akca, Saliha ;

Foroughi, Ashkan ;

Frochtzwajg, Daniel ;

Postma, Henk W. Ch. .

PLOS ONE, 2011, 6 (04)

[2] A perfect absorber made of a graphene micro-ribbon metamaterial [J].

Alaee, Rasoul ;

Farhat, Mohamed ;

Rockstuhl, Carsten ;

Lederer, Falk .

OPTICS EXPRESS, 2012, 20 (27) :28017-28024

[3] Electromechanical resonators from graphene sheets [J].

Bunch, J. Scott ;

van der Zande, Arend M. ;

Verbridge, Scott S. ;

Frank, Ian W. ;

Tanenbaum, David M. ;

Parpia, Jeevak M. ;

Craighead, Harold G. ;

McEuen, Paul L. .

SCIENCE, 2007, 315 (5811) :490-493

[4] Electrically Continuous Graphene from Single Crystal Copper Verified by Terahertz Conductance Spectroscopy and Micro Four-Point Probe [J].

Buron, Jonas D. ;

Pizzocchero, Filippo ;

Jessen, Bjarke S. ;

Booth, Timothy J. ;

Nielsen, Peter F. ;

Hansen, Ole ;

Hilke, Michael ;

Whiteway, Eric ;

Jepsen, Peter U. ;

Boggild, Peter ;

Petersen, Dirch H. .

NANO LETTERS, 2014, 14 (11) :6348-6355

[5] Graphene field effect transistor as a probe of electronic structure and charge transfer at organic molecule-graphene interfaces [J].

Cervenka, Jiri ;

Budi, Akin ;

Dontschuk, Nikolai ;

Stacey, Alastair ;

Tadich, Anton ;

Rietwyk, Kevin J. ;

Schenk, Alex ;

Edmonds, Mark T. ;

Yin, Yuefeng ;

Medhekar, Nikhil ;

Kalbac, Martin ;

Pakes, Chris I. .

NANOSCALE, 2015, 7 (04) :1471-1478

[6] Slot antenna as a bound charge oscillator [J].

Choe, Jong-Ho ;

Kang, Ji-Hun ;

Kim, Dai-Sik ;

Park, Q-Han .

OPTICS EXPRESS, 2012, 20 (06) :6521-6526

[7] Terahertz Nanoprobing of Semiconductor Surface Dynamics [J].

Choi, Geunchang ;

Bahk, Young-Mi ;

Kang, Taehee ;

Lee, Yoojin ;

Son, Byung Hee ;

Ahn, Yeong Hwan ;

Seo, Minah ;

Kim, Dai-Sik .

NANO LETTERS, 2017, 17 (10) :6397-6401

[8]

Crow JF, 1997, GENETICS, V147, P1491

[9] Monitoring dopants by Raman scattering in an electrochemically top-gated graphene transistor [J].

Das, A. ;

Pisana, S. ;

Chakraborty, B. ;

Piscanec, S. ;

Saha, S. K. ;

Waghmare, U. V. ;

Novoselov, K. S. ;

Krishnamurthy, H. R. ;

Geim, A. K. ;

Ferrari, A. C. ;

Sood, A. K. .

NATURE NANOTECHNOLOGY, 2008, 3 (04) :210-215

[10] Electrical Detection of DNA Hybridization with Single-Base Specificity Using Transistors Based on CVD-Grown Graphene Sheets [J].

Dong, Xiaochen ;

Shi, Yumeng ;

Huang, Wei ;

Chen, Peng ;

Li, Lain-Jong .

ADVANCED MATERIALS, 2010, 22 (14) :1649-+

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