Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives

被引：0
|
作者：
Chai Jie [1 ]
Yang Bin-Sheng [1 ]
Liu Bin [1 ]
机构：
[1] Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol Mol Engn, Educ Minist, Taiyuan 030006, Shanxi, Peoples R China
来源：
CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2018年 / 34卷 / 10期
关键词：
chromium picolinate; redox property; safety; antihyperglycemic effects; SMOOTH-MUSCLE-CELLS; IN-VITRO; ANTITUMOR-ACTIVITY; TSP-1; EXPRESSION; HIGH GLUCOSE; DNA-DAMAGE; COMPLEX; CRYSTAL; SUPPLEMENTATION; LIGAND;
D O I：
10.11862/CJIC.2018.217
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Four new chromium picolinate derivatives were synthesized and characterized by X-ray crystal diffraction, ESI-MS, analytical element, conductivity and IR analysis. The effect of substituent groups on its redox property and hydroxyl radical (center dot OH) generation induced by the complex were investigated by cyclic voltammetry and Fenton-like reaction. As a result, three complexes generate less center dot OH than Cr(pic)(3). Besides, acute toxicity and antihyperglycemic effect indicated that high dose of complex 3 is hypotoxic and exhibited more efficiency than Cr(pic)(3) in reducing fasten blood glucose (FBG) and low density lipoprotein by low dose.
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收藏
页码：1783 / 1791
页数：9
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