Quality of life improvement after a three-year course of sublingual immunotherapy in patients with house dust mite and grass pollen induced allergic rhinitis: results from real-life

被引：23

作者：

Novakova, Silviya Mihaylova ^{[1
]}

Staevska, Maria Toncheva ^{[2
]}

Novakova, Plamena Ivanova ^{[2
]}

Yoncheva, Manuela Dimitrova ^{[3
]}

Bratoycheva, Maria Stoykova ^{[4
]}

Musurlieva, Nina Mihaylova ^{[4
]}

Tzekov, Valeri Dimitrov ^{[5
]}

Nicolov, Dimitar Georgiev ^{[5
]}

机构：

[1] Univ Hosp St George, Allergy Unit, Internal Consulting Dept, Peshtersko Shosse 66, Plovdiv, Bulgaria

[2] Sofia Med Univ, Clin Allergy & Asthma, Georgi Sofiiski 1, Sofia, Bulgaria

[3] Univ Hosp St George, Internal Consulting Dept, Peshtersko Shosse 66, Plovdiv, Bulgaria

[4] Med Univ Plovdiv, Fac Publ Hlth, Dept Social Med & Publ Hlth, Vasil Aprilov 15A, Plovdiv, Bulgaria

[5] Med Univ Plovdiv, Med Fac, Internal Dept 2, Vassil Aprilov 15A, Plovdiv, Bulgaria

来源：

HEALTH AND QUALITY OF LIFE OUTCOMES | 2017年 / 15卷

关键词：

Allergic rhinitis; Quality of life; Sublingual immunotherapy; House dust mite; Grass pollen; Real life; Sensitization; ASTHMA; IMPACT; EFFICACY; RHINOCONJUNCTIVITIS; RECOMMENDATIONS; DISEASES; GA(2)LEN; TRIALS; UPDATE;

D O I：

10.1186/s12955-017-0764-z

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background: Along with its high prevalence, the burden of allergic rhinitis rests upon the serious impact on quality of life of patients. Allergic rhinitis is associated with impairments in daily activities, work and school performance, and practical problems. Patients suffer from sleep disorders and emotional problems. The advantages of sublingual immunotherapy on quality of life have only recently begun to emerge. The objective of this prospective real-life study was to evaluate the effect of a three-year course of sublingual immunotherapy with house dust mite (HDM) and grass pollen extracts on quality of life in adults with allergic rhinitis. Methods: A total number of 191 adult patients [105 (54,979%) men; mean age 27.3 years (SD-6.14)] with moderate to severe allergic rhinitis and clinically relevant sensitization to house dust mites or grass pollen were prospectively evaluated in the course of management of their disease. Health-related quality of life was assessed by Rhinoconjunctivitis Quality of Life Questionnaire at baseline and after three-year course of sublingual immunotherapy. Results: The mean overall Qol score assessed at baseline and at the end of the third year of treatment decreased significantly in patients treated with HDM extract (from 2.95 to 0.76) as well as with Grass pollen extract (from 2.83 to 1.22) (p < 0.001). The improvements in treated with HDM extract were as followed: activities - 3.52 to 0.68; sleep- 2.48 to 0.31; general problems - 1.79 to 0.49; practical problems - 3.57 to 0.68; nasal symptoms - 3.91 to 0.74; eye symptoms - 2.92 to 0.39; emotions - 3.03 to 0.39. The improvements in grass pollen group were: activities - 3.68 to 1.69; sleep- 1.85 to 0.84; general problems - 1.74 to 0.97; practical problems - 3.52 to 1.37; nasal symptoms - 3.72 to 1.57; eye symptoms - 3.58 to 1.3; emotions - 2.48 to 1.19. Conclusion: Our study conducted in real life provided evidence that a three-year course of SLIT with HDM extract as well as with grass pollen extract significantly increased QoL in patients with allergic rhinitis.

引用

页数：6

共 29 条

[1] Allergic diseases and their impact on quality of life [J].

Baiardini, Ilaria ;

Braido, Fulvio ;

Brandi, Silvia ;

Canonica, Giorgio Walter .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2006, 97 (04) :419-428

[2]

Blaiss M, 2011, J ALLERGY CLIN IMMUN, V127, P64, DOI 10.1016/j.jaci.2010.11.034

[3] Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen) [J].

Bousquet, J. ;

Khaltaev, N. ;

Cruz, A. A. ;

Denburg, J. ;

Fokkens, W. J. ;

Togias, A. ;

Zuberbier, T. ;

Baena-Cagnani, C. E. ;

Canonica, G. W. ;

van Weel, C. ;

Agache, I. ;

Ait-Khaled, N. ;

Bachert, C. ;

Blaiss, M. S. ;

Bonini, S. ;

Boulet, L. -P. ;

Bousquet, P. -J. ;

Camargos, P. ;

Carlsen, K. -H. ;

Chen, Y. ;

Custovic, A. ;

Dahl, R. ;

Demoly, P. ;

Douagui, H. ;

Durham, S. R. ;

van Wijk, R. Gerth ;

Kalayci, O. ;

Kaliner, M. A. ;

Kim, Y. -Y. ;

Kowalski, M. L. ;

Kuna, P. ;

Le, L. T. T. ;

Lemiere, C. ;

Li, J. ;

Lockey, R. F. ;

Mavale-Manuel, S. ;

Meltzer, E. O. ;

Mohammad, Y. ;

Mullol, J. ;

Naclerio, R. ;

Hehir, R. E. O. ;

Ohta, K. ;

Ouedraogo, S. ;

Palkonen, S. ;

Papadopoulos, N. ;

Passalacqua, G. ;

Pawankar, R. ;

Popov, T. A. ;

Rabe, K. F. ;

Rosado-Pinto, J. .

ALLERGY, 2008, 63 :8-+

[4] Severity and impairment of allergic rhinitis in patients consulting in primary care [J].

Bousquet, J ;

Neukirch, F ;

Bousquet, PJ ;

Gehano, P ;

Klossek, JM ;

Le Gal, M ;

Allaf, B .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (01) :158-162

[5] Severe Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA2LEN - ARIA Position Paper [J].

Bousquet, J. ;

Anto, J. M. ;

Demoly, P. ;

Schuenemann, H. J. ;

Togias, A. ;

Akdis, M. ;

Auffray, C. ;

Bachert, C. ;

Bieber, T. ;

Bousquet, P. J. ;

Carlsen, K. H. ;

Casale, T. B. ;

Cruz, A. A. ;

Keil, T. ;

Carlsen, K. C. Lodrup ;

Maurer, M. ;

Ohta, K. ;

Papadopoulos, N. G. ;

Rodriguez, M. Roman ;

Samolinski, B. ;

Agache, I. ;

Andrianarisoa, A. ;

Ang, C. S. ;

Annesi-Maesano, I. ;

Ballester, F. ;

Baena-Cagnani, C. E. ;

Basagana, X. ;

Bateman, E. D. ;

Bel, E. H. ;

Bedbrook, A. ;

Beghe, B. ;

Beji, M. ;

Ben Kheder, A. ;

Benet, M. ;

Bennoor, K. S. ;

Bergmann, K. C. ;

Berrissoul, F. ;

Jensen, C. Bindslev ;

Bleecker, E. R. ;

Bonini, S. ;

Boner, A. L. ;

Boulet, L. P. ;

Brightling, C. E. ;

Brozek, J. L. ;

Bush, A. ;

Busse, W. W. ;

Camargos, P. A. M. ;

Canonica, G. W. ;

Carr, W. ;

Cesario, A. .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2012, 158 (03) :216-231

[6] Practical guide to skin prick tests in allergy to aeroallergens [J].

Bousquet, J. ;

Heinzerling, L. ;

Bachert, C. ;

Papadopoulos, N. G. ;

Bousquet, P. J. ;

Burney, P. G. ;

Canonica, G. W. ;

Carlsen, K. H. ;

Cox, L. ;

Haahtela, T. ;

Carlsen, K. C. Lodrup ;

Price, D. ;

Samolinski, B. ;

Simons, F. E. R. ;

Wickman, M. ;

Annesi-Maesano, I. ;

Baena-Cagnani, C. E. ;

Bergmann, K. C. ;

Bindslev-Jensen, C. ;

Casale, T. B. ;

Chiriac, A. ;

Cruz, A. A. ;

Dubakiene, R. ;

Durham, S. R. ;

Fokkens, W. J. ;

Gerth-van-Wijk, R. ;

Kalayci, O. ;

Kowalski, M. L. ;

Mari, A. ;

Mullol, J. ;

Nazamova-Baranova, L. ;

O'Hehir, R. E. ;

Ohta, K. ;

Panzner, P. ;

Passalacqua, G. ;

Ring, J. ;

Rogala, B. ;

Romano, A. ;

Ryan, D. ;

Schmid-Grendelmeier, P. ;

Todo-Bom, A. ;

Valenta, R. ;

Woehrl, S. ;

Yusuf, O. M. ;

Zuberbier, T. ;

Demoly, P. .

ALLERGY, 2012, 67 (01) :18-24

[7] Uncontrolled allergic rhinitis during treatment and its impact on quality of life: A cluster randomized trial [J].

Bousquet, Philippe J. ;

Bachert, Claus ;

Canonica, Giorgo W. ;

Casale, Thomas B. ;

Mullol, Joaquim ;

Klossek, Jean Michel ;

Zuberbier, Torsten ;

Bousquet, Jean .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (03) :666-668

[8] Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care [J].

Bousquet, Philippe Jean ;

Demoly, Pascal ;

Devillier, Philippe ;

Mesbah, Kamal ;

Bousquet, Jean .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2013, 160 (04) :393-400

[9] Specific recommendations for PROs and HRQoL assessment in allergic rhinitis and/or asthma: a GA2LEN taskforce position paper [J].

Braido, F. ;

Bousquet, P. J. ;

Brzoza, Z. ;

Canonica, G. W. ;

Compalati, E. ;

Fiocchi, A. ;

Fokkens, W. ;

Gerth van Wijk, R. ;

La Grutta, S. ;

Lombardi, C. ;

Maurer, M. ;

Pinto, A. M. ;

Ridolo, E. ;

Senna, G. E. ;

Terreehorst, I. ;

Todo Bom, A. ;

Bousquet, J. ;

Zuberbier, T. ;

Baiardini, I. .

ALLERGY, 2010, 65 (08) :959-968

[10]

Brozek J, 2010, J ALLERGY CLIN IMMUN, V9, P1

← 1 2 3 →