Palmarumycins BG1-BG7 and Preussomerin BG1: Establishment of Their Absolute Configurations Using Theoretical Calculations of Electronic Circular Dichroisnn Spectra

被引：35

作者：

Cai, You-Sheng ^{[2
]}

Kurtan, Tibor ^{[1
]}

Ze-Hong Miao ^{[2
]}

Mandi, Attila ^{[3
]}

Komaromi, Istvan ^{[4
]}

Liu, Hai-Li ^{[2
]}

Ding, Jian ^{[2
]}

Guo, Yue-Wei ^{[2
]}

机构：

[1] Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary

[2] Chinese Acad Sci, State Key Lab Drug Res, Inst Mat Med, Shanghai 201203, Peoples R China

[3] Univ Debrecen, Hungarian Acad Sci, Res Grp Carbohydrates, H-4010 Debrecen, Hungary

[4] Univ Debrecen, Hungarian Acad Sci, Thrombosis Hemostasis & Vasc Biol Res Grp, H-4032 Debrecen, Hungary

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 06期

关键词：

BIOLOGICALLY-ACTIVE METABOLITES; MACROCYCLIC POLYDISULFIDE; STRUCTURE ELUCIDATION; ENDOPHYTIC FUNGUS; DEOXYPREUSSOMERINS; GYMNORRHIZOL;

D O I：

10.1021/jo1024877

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palmarumycins BG1-BG7 (1-7), seven new compounds related to palmarumycins, were isolated from the aerial parts of Bruguiera gymnorrhiza as well as a new preussomerin derivative BG1 (8). The structures of these compounds were determined mainly by the analysis of their NMR and MS data, and their relative configurations were assigned on the basis of their (3)J(H,H) coupling constants. Compounds 4 and 7 have a sulfate group that is unprecedented among members of spirodioxynaphthalene-type natural products. The absolute configurations of 1-8 were determined by TDDFT CD calculations of the solution conformers. Compound 5 displayed inhibitory activity against HL 60 and MCF-7 cell lines.

引用

页码：1821 / 1830

页数：10

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