MicroRNAs and cancer: Profile, profile, profile

被引：174

作者：

Barbarotto, Elisa ^{[1
,2
]}

Schmittgen, Thomas D. ^{[3
]}

Calin, George A. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX USA

[2] Univ Ferrara, Dept Morphol & Embryol, Human Anat Sect, I-44100 Ferrara, Italy

[3] Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2008年 / 122卷 / 05期

关键词：

microRNAs; noncoding RNAs; microarray; quantitative RT-PCR; cancer;

D O I：

10.1002/ijc.23343

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) represent a new class of small noncoding RNAs (ncRNAs, RNAs that do not codify for proteins) that can regulate gene expression by targeting messenger RNAs of protein coding genes and other ncRNA transcripts. miRNAs were recently found to be involved in the pathophysiology of all types of analyzed human cancers mainly by aberrant gene expression. This is characterized by abnormal levels of expression for mature and/or precursor miRNA transcripts in comparison to the corresponding normal tissues. miRNA profiling has allowed the identification of signatures associated with diagnosis, prognosis and response to treatment of human tumors. Therefore, miRNAs fingerprinting represents a new addition to the tools to be used by medical oncologists. (c) 2007 Wiley-Liss, Inc.

引用

页码：969 / 977

页数：9

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