Pharmacogenomics of platinum-based chemotherapy sensitivity in NSCLC: toward precision medicine

被引：34
作者：
Yin, Ji-Ye [1 ,2 ,3 ]
Li, Xi [1 ,2 ,3 ]
Zhou, Hong-Hao [1 ,2 ,3 ]
Liu, Zhao-Qian [1 ,2 ,3 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China
[2] Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China
[3] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China
来源：
PHARMACOGENOMICS | 2016年 / 17卷 / 12期
关键词：
chemotherapy sensitivity; NSCLC; pharmacogenomics; platinum; polymorphism; precision medicine; SNP; CELL LUNG-CANCER; SINGLE-NUCLEOTIDE POLYMORPHISMS; REPAIR GENE POLYMORPHISMS; REDUCTASE C677T POLYMORPHISM; DNA-REPAIR; CLINICAL-OUTCOMES; TREATMENT RESPONSE; 1ST-LINE PLATINUM; PREDICTIVE-VALUE; CHINESE PATIENTS;
D O I：
10.2217/pgs-2016-0074
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Lung cancer is one of the leading causes of cancer-related death in the world. Platinum based chemotherapy is the first-line treatment for non-small-cell lung cancer (NSCLC), however, the therapeutic efficiency varies remarkably among individuals. A large number of pharmacogenomics studies aimed to identify genetic variations which can be used to predict platinum response. Those studies are leading NSCLC treatment to the new era of precision medicine. In the current review, we provided a comprehensive update on the main recent findings of genetic variations which can be used to predict platinum sensitivity in the NSCLC patients.
引用
收藏
页码：1365 / 1378
页数：14
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