Removal of autoantibodies in dilated cardiomyopathy by immunoadsorption

被引：90

作者：

Wallukat, G ^{[1
]}

Reinke, P ^{[1
]}

Dorffel, WV ^{[1
]}

Luther, HP ^{[1
]}

Bestvater, K ^{[1
]}

Felix, SB ^{[1
]}

Baumann, G ^{[1
]}

机构：

[1] HUMBOLDT UNIV BERLIN,BERLIN,GERMANY

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 1996年 / 54卷 / 02期

关键词：

immunoadsorption; autoimmune diseases; dilated cardiomyopathy; anti-beta(1)-adrenoceptor autoantibody;

D O I：

10.1016/0167-5273(96)02598-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunoadsorption with Ig-Therasorb leads to a marked decrease in serum levels of immunoglobulins including of the agonist-like anti-beta(1)-adrenoceptor autoantibody found in the serum of patients with idiopathic dilated cardiomyopathy. The reduction in autoantibody levels was accompanied by an improvement of heart function and a shift to a lower NYHA state. In this disease, as in a variety of other autoimmune disorders, apheresis with Ig-Therasorb led to a rapid improvement of the clinical status and could be used in end-stage dilated cardiomyopathy (with autoantibodies) as a bridge for transplantation.

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收藏

页码：191 / 195

页数：5

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