Novel imidazole derivatives with subtype-selective antimuscarinic activity - (2)

被引：24

作者：

Miyachi, H ^{[1
]}

Kiyota, H ^{[1
]}

Segawa, M ^{[1
]}

机构：

[1] Kyorin Pharmaceut Co Ltd, Cent Res Labs, Nogi, Tochigi 3290114, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(98)00393-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-(2-methylimidazol-1-yl)-2.2-diphenyltlutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for Mt and M-3 muscarinic receptors, the structure-activity relationships of these compounds are discussed, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2163 / 2168

页数：6

共 5 条

[1] NEW TRENDS IN LOWER URINARY-TRACT PHARMACOLOGY [J].

ANDERSSON, KE .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1984, 5 (12) :521-523

[2] COMPARISON OF AFFINITY CONSTANTS FOR MUSCARINE-SENSITIVE ACETYLCHOLINE RECEPTORS IN GUINEA-PIG ATRIAL PACEMAKER CELLS AT 29 DEGREESC AND IN ILEUM AT 29 DEGREESC AND 37 DEGREESC [J].

BARLOW, RB ;

BERRY, KJ ;

GLENTON, PAM ;

NIKOLAOU, NM ;

SOH, KS .

BRITISH JOURNAL OF PHARMACOLOGY, 1976, 58 (04) :613-620

[3] ANALOGS OF OXYBUTYNIN - SYNTHESIS AND ANTIMUSCARINIC AND BLADDER ACTIVITY OF SOME SUBSTITUTED 7-AMINO-1-HYDROXY-5-HEPTYN-2-ONES AND RELATED-COMPOUNDS [J].

CARTER, JP ;

NORONHABLOB, L ;

AUDIA, VH ;

DUPONT, AC ;

MCPHERSON, DW ;

NATALIE, KJ ;

RZESZOTARSKI, WJ ;

SPAGNUOLO, CJ ;

WAID, PP ;

KAISER, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (10) :3065-3074

[4] DIFFERENTIAL BLOCKADE OF MUSCARINIC RECEPTOR SUBTYPES BY POLYMETHYLENE TETRAAMINES - NOVEL CLASS OF SELECTIVE ANTAGONISTS OF CARDIAC M-2 MUSCARINIC RECEPTORS [J].

MELCHIORRE, C ;

CASSINELLI, A ;

QUAGLIA, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (01) :201-204

[5]

MIYACHI H, IN PRESS BIOORG MED

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