A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians' relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity

被引：37

作者：

Corsonello, Andrea ^{[2
]}

Montesanto, Alberto ^{[1
]}

Berardelli, Maurizio ^{[1
]}

De Rango, Francesco ^{[1
]}

Dato, Serena ^{[1
]}

Mari, Vincenzo ^{[2
]}

Mazzei, Bruno ^{[2
]}

Lattanzio, Fabrizia ^{[3
]}

Passarino, Giuseppe ^{[1
]}

机构：

[1] Univ Calabria, Dept Cell Biol, I-87036 Arcavacata Di Rende, CS, Italy

[2] INRCA, Cosenza, Italy

[3] INRCA, Sci Direct, Ancona, Italy

来源：

AGE AND AGEING | 2010年 / 39卷 / 06期

关键词：

ageing; thyroid; survival; free-triiodothyronine; elderly; EUTHYROID SICK SYNDROME; DYSFUNCTION; DISABILITY; SURVIVAL;

D O I：

10.1093/ageing/afq116

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives: to verify whether declining levels of circulating thyroid hormones may contribute to longevity. Design: cross-sectional observational study. Setting: all subjects were born in Calabria (southern Italy) and their ancestry in the region was ascertained up to the grandparents. Subjects: six hundred and four home-dwelling subjects (301 females, 303 males), divided into three groups: 278 individuals 60-85 years old; 179 children or nieces/nephews of centenarians who are 60-85 years old; 147 individuals older than 85 years. Methods: thyroid function parameters were measured in the frame of a comprehensive geriatric assessment. Results: FT3 and FT4 levels were negatively associated with age. Lower levels of FT3, FT4 and TSH were found in centenarians' children and nieces/nephews with respect to age-matched controls. Indeed, being a relative of centenarians qualified as an independent correlate of thyroid parameters. Conclusions: age-related subtle thyroid hypofunction (either due to a familial component or due to a reset of the thyroid function occurring between the sixth and the eighth decade of life) appears to be related to longevity.

引用

页码：723 / 727

页数：5