Hyperinsulinemia negatively affects the association between insulin resistance and blood pressure

被引:6
|
作者
Fan, Jie [1 ]
Liu, Lian Yong [2 ]
Liu, Xing Zhen [3 ]
机构
[1] Zhejiang Police Coll, Dept Traff Management Engn, 555 Binwen Rd, Hangzhou, Peoples R China
[2] Punan Hosp Pudong New Dist, Dept Endocrinol, 279 Linyi Rd, Shanghai 200336, Peoples R China
[3] Hangzhou Aeronaut Sanat Special Serv China Air Fo, 27 Yang Gong Di, Hangzhou 310007, Zhejiang, Peoples R China
关键词
Hypertension; Hypertrigly-ceridemia; Insulin resistance; Moderation analysis; HYPERTENSION; GLUCOSE;
D O I
10.1016/j.numecd.2021.08.029
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and aims: Although hyperinsulinemia and insulin resistance (IR) together cause metabolic diseases, the available evidence fails to link hyperinsulinemia with blood pressure (BP) elevation. To further understand the role of hyperinsulinemia in the pathophysiology of hypertension, we conducted this study to investigate the moderating effect of fasting insulin (FINS) on the association between IR and BP. Methods and results: The health screening data of 72,076 individuals were analyzed for this moderation analysis. IR was indicated by the homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride-glucose index (TyG), and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDLc). In the adjusted model, three IR indicators were considered independent variables; FINS was used as a moderator, and systolic BP (SBP) and diastolic BP (DBP) were used as dependent variables. The regression coefficient of the interaction term between the three IR indicators and FINS was significantly negative in all moderation models. Simple slope tests and the Johnson-Neymann technique also indicated that FINS negatively moderated the association between IR and BP. Conclusions: This moderation analysis showed that FINS negatively mediated the association between IR and BP, suggesting that hyperinsulinemia may buffer, not reinforce, the effect of IR on hypertension. (c) 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:3359 / 3366
页数:8
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