Structure - Bioactivity Relationship in Cyclic Peptoids: An Overview

被引:8
作者
D'Amato, Assunta [1 ]
机构
[1] Univ Salerno, Dept Chem & Biol A Zambelli, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy
关键词
Bioactive compounds; Macrocycles; Peptoids; Peptidomimetics; Pharmaceutical chemistry; PROTEIN-PROTEIN INTERACTIONS; ANTIMICROBIAL PEPTIDES; BIOLOGICAL-ACTIVITIES; CELL-PERMEABILITY; MODULAR APPROACH; BINDING; POTENT; INHIBITORS; VERTICILIDE; CYCLIZATION;
D O I
10.1002/ejoc.202200665
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Cyclic N-substituted glycines oligomers, also known as cyclic peptoids, constitute a promising class of novel peptidomimetics, capable of simulating bioactive effectors with enhanced proteolytical stability and cell permeability as crucial bonuses. The macrocyclic constraint, essential for the induction of stable secondary structures, determines the biomimetic potential of such molecules, which act as antimicrobials, cytotoxic agents, siderophores, glycosidases inhibitors and so on. The bioactivity can be either attributed to the macrocyclic core (especially chelation) or to the side-chains (when endowed with specific groups or pharmacophores). The structure-bioactivity correlations emerging for this class of peptidomimetics, based on the study of conformational order and morphology of the backbone architecture, unravel interesting avenues for the rational design of more effective cyclooligomeric biomimics.
引用
收藏
页数:13
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