Methods of the Analysis of Oxylipins in Biological Samples

被引：35
作者：
Liakh, Ivan [1 ]
Pakiet, Alicja [2 ]
Sledzinski, Tomasz [1 ]
Mika, Adriana [1 ,2 ]
机构：
[1] Med Univ Gdansk, Dept Pharmaceut Biochem, Debinki 1, PL-80211 Gdansk, Poland
[2] Univ Gdansk, Fac Chem, Dept Environm Anal, Wita Stwosza 63, PL-80308 Gdansk, Poland
来源：
MOLECULES | 2020年 / 25卷 / 02期
关键词：
oxylipins; biological samples; HPLC; UHPLC; GC-MS; LC-MS; PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; ARACHIDONIC-ACID METABOLITES; POLYUNSATURATED FATTY-ACIDS; HUMAN PLASMA; LC-MS/MS; ELECTROSPRAY-IONIZATION; SIMULTANEOUS QUANTIFICATION; AUTOMATED IDENTIFICATION; LIPID-PEROXIDATION;
D O I：
10.3390/molecules25020349
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxylipins are derivatives of polyunsaturated fatty acids and due to their important and diverse functions in the body, they have become a popular subject of studies. The main challenge for researchers is their low stability and often very low concentration in samples. Therefore, in recent years there have been developments in the extraction and analysis methods of oxylipins. New approaches in extraction methods were described in our previous review. In turn, the old analysis methods have been replaced by new approaches based on mass spectrometry (MS) coupled with liquid chromatography (LC) and gas chromatography (GC), and the best of these methods allow hundreds of oxylipins to be quantitatively identified. This review presents comparative and comprehensive information on the progress of various methods used by various authors to achieve the best results in the analysis of oxylipins in biological samples.
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页数：33
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