Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy

被引:43
作者
Blamire, Andrew M.
Cader, Sarah
Lee, Martin
Palace, Jackie
Matthews, Paul M.
机构
[1] Univ Newcastle Upon Tyne, Newcastle Magnet Resonance Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Univ Oxford, Dept Clin Neurol, Ctr Funct Magnet Resonance Imaging Brain, Oxford, England
[3] Univ Newcastle Upon Tyne, Sch Clin & Lab Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
基金
英国医学研究理事会;
关键词
proton spectroscopy; MRS; cervical spinal cord; N-acetyl-aspartate; multiple sclerosis;
D O I
10.1002/mrm.21382
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Axonal damage is a major factor contributing to permanent disability in patients with multiple sclerosis (MS); it has been extensively investigated in the brain using magnetic resonance spectroscopy (MRS). In this study, MRS was used to investigate the degree of neuronal damage in the cervical spinal cord in MS. Spectra were acquired from spinal cord and brain in 11 patients with MS (expanded disability status score [EDSS], range 2.5-7.0) and 11 controls. Brain lesion volume and spinal cord cross-sectional area were measured. Concentration of the neuronal metabolite N-acetyl-aspartate ([NAA]) was reduced in the spinal cord in MS patients relative to controls (reduced by 32%, P < 0.05), indicating significant neuronal damage. Additionally, the spinal cord was significantly atrophied in MS patients (15%, P < 0.001). No significant reduction in brain [NAA] was seen in the MS group. There were no correlations between clinical measures and cord atrophy or brain lesion volume on MRI; however, spinal cord [NAA] correlated with the cerebellar subscore of the neurological assessment (P < 0.005), while brain [NAA] correlated with disease duration (P < 0.05). MRS demonstrated cellular damage within the cord over and above the tissue atrophy seen by MRI. Combining MRI and MRS may therefore give a more complete picture of neurodegeneration in the spinal cord.
引用
收藏
页码:880 / 885
页数:6
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