Advances in nanomaterials for brain microscopy

被引：12

作者：

Del Bonis-O'Donnell, Jackson T. ^{[1
]}

Chio, Linda ^{[1
]}

Dorlhiac, Gabriel F. ^{[2
]}

McFarlane, Ian R. ^{[1
]}

Landry, Markita P. ^{[1
,3
,4
,5
]}

机构：

[1] Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Biophys Grad Grp, Berkeley, CA 94720 USA

[3] Innovat Genom Inst, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Calif Inst Quantitat Biosci, QB3, Berkeley, CA 94720 USA

[5] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

来源：

NANO RESEARCH | 2018年 / 11卷 / 10期

关键词：

nanomaterials; neuroscience; imaging; microscopy; WALLED CARBON NANOTUBES; GRAPHENE QUANTUM DOTS; NEAR-INFRARED WINDOW; ENHANCED RAMAN-SPECTROSCOPY; LIGHT-SHEET MICROSCOPY; IMAGING IN-VIVO; GOLD NANOPARTICLES; EXTRACELLULAR-SPACE; MOUSE-BRAIN; DRUG-DELIVERY;

D O I：

10.1007/s12274-018-2145-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Microscopic imaging of the brain continues to reveal details of its structure, connectivity, and function. To further improve our understanding of the emergent properties and functions of neural circuits, we need to directly visualize the relationship between brain structure, neuron activity, and neurochemistry. Advances in the chemical and optical properties of nanomaterials, and developments in deep-tissue microscopy, may help to overcome the current challenges of in-vivo brain imaging, particularly when imaging the brain through optically-dense brain tissue, skull, and scalp. Developments in nanomaterials may enable the implementation of tunable chemical functionality for neurochemical targeting and sensing, and fluorescence stability for long-term imaging. In this review, we summarize the current methods used for brain microscopy and describe the diverse classes of nanomaterials recently offered as contrast agents and functional probes for microscopic optical imaging of the brain.

引用

页码：5144 / 5172

页数：29

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