Ethyl (2,5-dioxo-1-phenyl-2,3-dihydro-1H,5H-1-benzofuro[3,2-d]imidazo[1,2-a]pyrimidin-3-yl)acetate

被引：0

作者：

Deng, Shou-Heng ^{[1
]}

Cao, Feng-Jun ^{[1
]}

Cai, Xiao-Jun ^{[1
]}

Li, Fang ^{[1
]}

Chen, Ping ^{[1
]}

机构：

[1] Hubei Med Univ, Ctr Oncol, Peoples Hosp, Shiyan 442000, Hubei, Peoples R China

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2010年 / 66卷

关键词：

INHIBITORS;

D O I：

10.1107/S1600536810029521

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the title compound, C22H17N3O5, synthesized via the aza-Wittig reaction of ethyl 3-(phenyliminomethyleneamino)benzofuran-2-carboxylate, benzene isocyanate and diethyl 2-aminosuccinate, the imidazo[1,2-a]benzo[4,5]furo[2,3-d]pyrimidine ring system is essentially planar (r.m.s. deviation for all 16 non-H atoms = 0.020 A). The phenyl ring is twisted with respect to this ring system, making a dihedral angle of 54.23 (4)degrees. The crystal packing is stabilized by weak intermolecular C-H...O interactions.

引用

页码：O2173 / U2559

页数：11

共 14 条

[1] New arylpyrido-diazepine and -thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase
Bellarosa, D
Antonelli, G
Bambacioni, F
Giannotti, D
Viti, G
Nannicini, R
Giachetti, A
Dianzani, F
Witvrouw, M
Pauwels, R
Desmyter, J
DeClercq, E
[J]. ANTIVIRAL RESEARCH, 1996, 30 (2-3) : 109 - 124
[2] Bodke Y, 2003, J INDIAN CHEM SOC, V80, P187
[3] Bruker, 2001, SMART SAINT PLUS
[4] Structure-activity relationship study of novel tissue transglutaminase inhibitors
Duval, E
Case, A
Stein, RL
Cuny, GD
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (07) : 1885 - 1889
[5] Ethyl 2-[1-(4-chlorophenyl)-2,5-dioxo-1,2,3,5-tetrahydroimidazo[1′,2′:1,2]-pyrimidino[5,4-b][1]benzofuran-3-yl]-acetate
Hu, Yang-Gen
Zhu, Zheng-Rong
Chen, Yu-Lu
[J]. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : 0321 - U5500
[6] Ethyl 6-methyl-2-(3-nitrophenoxy)-4-oxo-3-phenyl-3,4-dihydrofuro[2,3-d] pyrimidine-5-carboxylate
Hu, Yang-Gen
Li, Gui-Hua
Zhou, Ming-Hua
[J]. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O1836 - O1838
[7] 3-(4-Methylphenyl)-2-(1-pyridyl)-3H-benzo[4,5]furo[3,2-d]pyrimidin-4-one
Hu, YG
Zheng, AH
Li, GH
[J]. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O1457 - O1459
[8] 3-(4-Methoxyphenoxy)-2-phenyl-3H-1-benzofuro-[3,2-d]pyrimidin-1-one
Hu, YG
Li, GH
Tian, JH
Ding, MW
He, HW
[J]. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2005, 61 : O3266 - O3268
[9] Synthesis of new furo[2,3-d]pyrimidines and Pyrimido[4′,5′:4,5]furo[2,3-d]pyrimidines
Moneam, MIA
Geies, AA
El-Naggar, GM
Mousa, SM
[J]. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2004, 51 (06) : 1357 - 1366
[10] The aza-Wittig reaction: an efficient tool for the construction of carbon-nitrogen double bonds
Palacios, Francisco
Alonso, Concepcion
Aparicio, Dornitila
Rubiales, Gloria
de los Santos, Jesus M.
[J]. TETRAHEDRON, 2007, 63 (03) : 523 - 575

← 1 2 →