Type 2 Diabetes, Hypoglycemia, and Basal Insulins: Ongoing Challenges

被引:11
作者
Blumer, Ian [1 ,2 ]
Clement, Maureen [3 ]
机构
[1] Charles H Best Diabet Ctr, Ajax, ON, Canada
[2] Univ Toronto, Dept Med, Toronto, ON, Canada
[3] Univ British Columbia, Diabet Educ Ctr, Vernon, BC, Canada
关键词
basal insulin; hypoglycemia; management; type; 2; diabetes; TO-TARGET TRIAL; PATIENT-REPORTED OUTCOMES; GLARGINE; 100; UNITS/ML; GLYCEMIC CONTROL; COGNITIVE FUNCTION; GLUCOSE CONTROL; NPH INSULIN; PEOPLE; DEGLUDEC; RISK;
D O I
10.1016/j.clinthera.2016.09.020
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hypoglycemia in people with insulin-treated type 2 diabetes can be a limiting factor for management and a barrier to optimizing glycemic control. Even mild episodes of hypoglycemia can affect an individual's quality of life, and fear of hypoglycemia can lead to underinsulinization. This article explores the prevalence and consequences of hypoglycemia in people with type 2 diabetes with a focus on those who use basal insulins, offering strategies for prevention and management. It also discusses the benefits and challenges associated with new basal insulins, and their potential role in reducing hypoglycemia risk. (C) 2017 Elsevier HS Journals, Inc. All rights reserved.
引用
收藏
页码:S1 / S11
页数:11
相关论文
共 50 条
  • [21] Achieve control: a pragmatic clinical trial of insulin glargine 300 U/mL versus other basal insulins in insulin-naive patients with type 2 diabetes
    Oster, Gerry
    Sullivan, Sean D.
    Dalal, Mehul R.
    Kazemi, Mahmood R.
    Rojeski, Maria
    Wysham, Carol H.
    Sung, Jennifer
    Johnstone, Bryan
    Cali, Anna M. G.
    Wei, L. J.
    Traylor, Louise
    Anhalt, Henry
    Hull, Michelle
    Van Vleet, John
    Meneghini, Luigi F.
    POSTGRADUATE MEDICINE, 2016, 128 (08) : 731 - 739
  • [22] Basal Insulin Initiation in Elderly Patients with Type 2 Diabetes in Taiwan: A Comparison with Younger Patients
    Chien, Ming-Nan
    Lee, Chun-Chuan
    Liu, Sung-Chen
    Chen, Wei-Che
    Leung, Ching-Hsiang
    Wang, Chao-Hung
    INTERNATIONAL JOURNAL OF GERONTOLOGY, 2015, 9 (03) : 142 - 145
  • [23] Insulin Degludec: Reduction of Hypoglycemia during Basal-Bolus Therapy in Patients with Diabetes Mellitus Type 1 or 2
    Luedemann, J.
    Merker, L.
    Milek, K.
    Kaiser, M.
    Wilhelm, B.
    DIABETOLOGIE UND STOFFWECHSEL, 2013, 8 (01) : 35 - 42
  • [24] Hypoglycemia and Comorbidities in Type 2 Diabetes
    Kong, Alice P. S.
    Chan, Juliana C. N.
    CURRENT DIABETES REPORTS, 2015, 15 (10)
  • [25] A study to assess the unmet medical needs associated with the use of basal insulin in patients with type 2 diabetes
    Frechtel, Gustavo
    Forti, Lujan
    Faingold, Cristina
    Mangui, Federico Perez
    Orio, Silvia
    Issa, Claudia
    Guaita, Maria S.
    Vivas, Norma
    De Luca, Julian A.
    ENDOCRINOLOGY DIABETES & METABOLISM, 2021, 4 (01)
  • [26] Safety and Efficacy of Long-Acting Insulins Degludec and Glargine Among Asian Patients With Type 2 Diabetes Mellitus: A Meta-Analysis
    Kant, Ravi
    Yadav, Poonam
    Garg, Mohit
    Bahurupi, Yogesh
    Kumar, Barun
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (06)
  • [27] Insulins for Type 2 Diabetes
    不详
    MEDICAL LETTER ON DRUGS AND THERAPEUTICS, 2019, 61 (1571): : 65 - 68
  • [28] Insulin Matters: A Practical Approach to Basal Insulin Management in Type 2 Diabetes
    Berard, Lori
    Antonishyn, Noreen
    Arcudi, Kathryn
    Blunden, Sarah
    Cheng, Alice
    Goldenberg, Ronald
    Harris, Stewart
    Jones, Shelley
    Mehan, Upender
    Morrell, James
    Roscoe, Robert
    Siemens, Rick
    Vallis, Michael
    Yale, Jean-Francois
    DIABETES THERAPY, 2018, 9 (02) : 501 - 519
  • [29] Update Use of modern Basal Insulin in old People with Type 2 Diabetes
    Dewerth, A.
    JOURNAL FUR KARDIOLOGIE, 2019, 26 (5-6): : 152 - 154
  • [30] Impact of severe and symptomatic hypoglycemia on quality of life and fear of hypoglycemia in type 1 and type 2 diabetes. Results of the Hypos-1 observational study
    Rossi, Maria Chiara
    Nicolucci, Antonio
    Ozzello, Alessandro
    Gentile, Sandro
    Aglialoro, Alberto
    Chiambretti, Anna
    Baccetti, Fabio
    Gentile, Francesco M.
    Romeo, Francesco
    Lucisano, Giuseppe
    Giorda, Carlo B.
    Fornengo, R.
    Nada, E.
    Ozzello, A.
    Sciangula, L.
    Musacchio, N.
    Marelli, G.
    Corsi, A.
    Baccetti, F.
    Paciotti, V
    L'Aquila, R. Iannarelli
    Antenucci, D.
    Chiaramonte, F.
    Leotta, S.
    Gentile, S.
    Armentano, V
    Gentile, F. M.
    Mastinu, E.
    Cucinotta, D.
    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2019, 29 (07) : 736 - 743