Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C5H5FeC5H4CO2SbPh4 and (C5H5FeC,5H4CO2)2Sb(4-CH3C6H4)3

被引：49

作者：

Liu, RC

Ma, YQ

Yu, L

Li, JS ^{[1
]}

Cui, JR

Wang, RQ

机构：

[1] Nankai Univ, State Key Lab ElementoOrgan Chem, Tianjin 300071, Peoples R China

[2] Peking Univ, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2003年 / 17卷 / 09期

关键词：

arylantimony; ferrocenecarboxylate; crystal structure; antitumor activity;

D O I：

10.1002/aoc.491

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of arylantimony ferrocenecarboxylates with the formula (C5H5FeC5H4CO2)(n)SbAr(5-n) (n = 1, 2; Ar = C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6H4, 4-CIC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, H-1 NMR and mass spectra. The crystal structures Of (C5H5FeC5H4CO2)(2)Sb(4-CH3C6H4)(3) and C5H5FeC5H4CO2SbPh4 were determined by X-ray diffraction. Four human neoplastic cell lines (HL-60, Bel-7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 mum show certain in vitro antitumor activities. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：662 / 668

页数：7

共 29 条

[1]

BAJPAI K, 1979, INDIAN J CHEM A, V18, P73

[2] MOLECULAR STRUCTURE OF TETRAPHENYLANTIMONY HYDROXIDE [J].