5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver

被引：81

作者：

Xu, Yong ^{[1
,3
,4
]}

Berglund, Eric D. ^{[1
,3
]}

Sohn, Jong-Woo ^{[1
,3
]}

Holland, William L. ^{[2
]}

Chuang, Jen-Chieh ^{[1
,3
]}

Fukuda, Makoto ^{[1
,3
]}

Rossi, Jari ^{[1
,3
]}

Williams, W. ^{[1
,3
]}

Jones, Juli E. ^{[5
]}

Zigman, Jeffrey M. ^{[1
,3
]}

Lowell, Bradford B. ^{[5
]}

Scherer, Philipp E. ^{[2
]}

Elmquist, Joel K. ^{[1
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Div Hypothalam Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

[4] Baylor Coll Med, Childrens Nutr Res Ctr, Dept Pediat, Houston, TX 77030 USA

[5] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA 02215 USA

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 12期

关键词：

MELANOCORTIN SYSTEM; RAT; HOMEOSTASIS; PATHWAYS; BRAIN;

D O I：

10.1038/nn.2664

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT2CR deficiency also abolished the anti-diabetic effects of meta-chlorophenylpiperazine (a 5-HT2CR agonist); these effects were restored when 5-HT(2C)Rs were re-expressed in POMC neurons. Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver.

引用

页码：1457 / 1459

页数：3

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