COVID-19 in chronic myeloid leukemia patients in Latin America

被引：5

作者：

Pagnano, Katia B. ^{[1
]}

Peralta, Evelyn Herrera ^{[2
]}

Navarro, Juan Ramon ^{[2
]}

David Salas, Lourdes del Rosario ^{[2
]}

Delgado, Nancy ^{[3
]}

Moiraghi, Beatriz ^{[4
]}

Toreli, Ana Carolina M. ^{[5
]}

Perobelli, Leila M. ^{[5
]}

Fechio, Leonardo ^{[1
]}

Quixada, Acy T. S. ^{[6
]}

Funke, Vaneuza ^{[7
]}

Bendit, Israel ^{[8
]}

Seguro, Fernanda S. ^{[9
]}

Pilleux, Lilian ^{[10
]}

Bortolini, Jaisson ^{[11
]}

Lourenco, Andre L. G. ^{[12
]}

Sapelli, Jaqueline ^{[13
]}

Nucci, Fabio M. ^{[14
]}

Pavlovsky, Carolina ^{[15
]}

Oliveira, Luciene Da Cruz ^{[16
]}

Moura, Muriel Silva ^{[17
]}

Palma, Leonardo C. ^{[18
]}

Goncalves, Natalia N. ^{[19
]}

Conchon, Monika ^{[19
]}

Hokama, Paula O. M. ^{[20
]}

Almeida, Leandro Lustri ^{[20
]}

Zulli, Roberto ^{[1
]}

de Souza, Carmino Antonio ^{[1
]}

Boquimpani, Carla M. ^{[21
]}

机构：

[1] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Rua Carlos Chagas 480, BR-13083878 Campinas, SP, Brazil

[2] Hosp Nacl Edgardo Rebagliati Martins, Jesus Maria, Peru

[3] Ctr Med Nacl Siglo XXI IMSS, Ciudad De Mexico, Mexico

[4] JM Ramos Mejia CABA, Buenos Aires, DF, Argentina

[5] Hosp Transplantes Euryclides Jesus Zerbini, Sao Paulo, Brazil

[6] Univ Fed Ceara, Fac Med, Hosp Univ Walter Cantidio, Fortaleza, Ceara, Brazil

[7] Univ Fed Parana, Complexo Hosp Clin, Curitiba, Parana, Brazil

[8] Univ Sao Paulo, Lab Med Invest Pathogenesis & Targeted Therapy On, Hosp Clin, Fac Med, Sao Paulo, Brazil

[9] Univ Sao Paulo, Hosp Clin, Fac Med, Sao Paulo, Brazil

[10] Hosp Valdivia, Bueras, Los Rios, Chile

[11] Ctr Pesquisas Oncol, Florianopolis, SC, Brazil

[12] Hosp Fornecedores Cana Piracicaba, Piracicaba, Brazil

[13] Hosp AC Camargo Canc Ctr, Sao Paulo, Brazil

[14] Univ Fed Fluminense, Hosp Univ Antonio Pedro, Niteroi, RJ, Brazil

[15] Hospitalizat & Clin Res Ctr, Fundaleu, Caba, Argentina

[16] Hosp Jorge Valente, Salvador, BA, Brazil

[17] Hosp Santa Casa Misericordia Maceio, Maceio, Alagoas, Brazil

[18] Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin, Ribeirao Preto, Brazil

[19] Hosp Santa Marcelina, Sao Paulo, Brazil

[20] Sao Paulo State Univ, Med Sch, UNESP, Campus Botucatu, Botucatu, SP, Brazil

[21] Hemorio, Rio De Janeiro, Brazil

来源：

LEUKEMIA & LYMPHOMA | 2021年 / 62卷 / 13期

关键词：

chronic myeloid leukemia; COVID-19; survival; molecular response; SARS-COV-2; INFECTION;

D O I：

10.1080/10428194.2021.1950709

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This observational, multicenter study aimed to report the clinical evolution of COVID-19 in patients with chronic myeloid leukemia in Latin America. A total of 92 patients presented with COVID-19 between March and December 2020, 26% of whom were severe or critical. The median age at COVID-19 diagnosis was 48 years (22-79 years), 32% were 60 years or older, and 61% were male. Thirty-nine patients presented with at least one comorbidity (42.3%). Eighty-one patients recovered (88%), and 11 (11.9%) died from COVID-19. There was one case of reinfection. Patients with a major molecular response presented superior overall survival compared to patients with no major molecular response (91 vs. 61%, respectively; p = 0.004). Patients in treatment-free remission and receiving tyrosine kinase inhibitors showed higher survival rates than patients who underwent hematopoietic stem cell transplantation and those who did not receive tyrosine kinase inhibitors (100, 89, 50, and 33%, respectively; p < 0.001).

引用

页码：3212 / 3218

页数：7

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