A nonacid degradable linker for solid-phase synthesis

被引：7

作者：

Colombo, Aina

De la Figuera, Natalia

Fernandez, Joan Carles

Fernandez-Forner, Dolors

Albericio, Fernando

Forns, Pilar

机构：

[1] Almirall Barcelona Sci Pk Unit, E-08028 Barcelona, Spain

[2] Res Ctr, Almirall & Prodesfarma, E-08024 Barcelona, Spain

[3] Univ Barcelona, Inst Res Biomed, Barcelona Sci Pk, E-08028 Barcelona, Spain

[4] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 21期

关键词：

D O I：

10.1021/ol701879s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building block and cleavage and in terms of higher purity of the final product. Use of linker 2 avoids side reactions associated with the use of Wang resin due to an undesired cleavage during final acid treatment.

引用

收藏

页码：4319 / 4322

页数：4

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