A nonacid degradable linker for solid-phase synthesis

被引：6
|
作者：
Colombo, Aina
De la Figuera, Natalia
Fernandez, Joan Carles
Fernandez-Forner, Dolors
Albericio, Fernando
Forns, Pilar
机构：
[1] Almirall Barcelona Sci Pk Unit, E-08028 Barcelona, Spain
[2] Res Ctr, Almirall & Prodesfarma, E-08024 Barcelona, Spain
[3] Univ Barcelona, Inst Res Biomed, Barcelona Sci Pk, E-08028 Barcelona, Spain
[4] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 21期
关键词：
D O I：
10.1021/ol701879s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building block and cleavage and in terms of higher purity of the final product. Use of linker 2 avoids side reactions associated with the use of Wang resin due to an undesired cleavage during final acid treatment.
引用
收藏
页码：4319 / 4322
页数：4
相关论文
共 50 条
  • [1] Novel linker for the solid-phase synthesis of guanidines
    Josey, JA
    Tarlton, CA
    Payne, CE
    TETRAHEDRON LETTERS, 1998, 39 (33) : 5899 - 5902
  • [2] Backbone Amide Linker in Solid-Phase Synthesis
    Boas, Ulrik
    Brask, Jesper
    Jensen, Knud J.
    CHEMICAL REVIEWS, 2009, 109 (05) : 2092 - 2118
  • [3] Boronate linker for 'traceless' solid-phase synthesis
    Pourbaix, C
    Carreaux, F
    Carboni, B
    Deleuze, H
    CHEMICAL COMMUNICATIONS, 2000, (14) : 1275 - 1276
  • [4] A novel linker strategy for solid-phase synthesis
    Morphy, JR
    Rankovic, Z
    Rees, DC
    TETRAHEDRON LETTERS, 1996, 37 (18) : 3209 - 3212
  • [5] A Universal Allyl Linker for Solid-Phase Synthesis
    Tetrahedron Lett, 22 (3789):
  • [6] New selenyl linker for solid-phase synthesis of dehydropeptides
    Nakamura, K
    Ohnishi, Y
    Horikawa, E
    Konakahara, T
    Kodaka, M
    Okuno, H
    TETRAHEDRON LETTERS, 2003, 44 (29) : 5445 - 5448
  • [7] Diversity linker units for solid-phase organic synthesis
    Scott, Peter J. H.
    Steel, Patrick G.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2006, 2006 (10) : 2251 - 2268
  • [8] A universal allyl linker for solid-phase synthesis.
    Zhang, XH
    Jones, RA
    TETRAHEDRON LETTERS, 1996, 37 (22) : 3789 - 3790
  • [9] A novel, thioacetal based linker for solid-phase synthesis
    Huwe, CM
    Künzer, H
    TETRAHEDRON LETTERS, 1999, 40 (04) : 683 - 686
  • [10] Synthesis of silicon traceless linker for solid-phase reaction
    Mun, HS
    Jeong, JH
    ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (04) : 371 - 375
12345