An isolated compound from stems and leaves of Coix lacryma-jobi L. and its anticancer effect

被引：6

作者：

Yu, Qiaorong ^{[1
]}

Ye, Guangbin ^{[2
,3
]}

Lei, Zhidong ^{[1
]}

Yang, Ruirui ^{[2
]}

Chen, Ran ^{[2
]}

He, Tingting ^{[2
]}

Huang, Suoyi ^{[1
,2
]}

机构：

[1] Youjiang Med Univ Natlionalities, Sch Pharm, Baise 533000, Guangxi, Peoples R China

[2] Youjiang Med Univ Nationalities, Sci Expt Ctr, Baise 533000, Guangxi, Peoples R China

[3] Guangxi Univ, Med Coll, Nanning 530004, Guangxi, Peoples R China

来源：

FOOD BIOSCIENCE | 2021年 / 42卷

基金：

美国国家科学基金会;

关键词：

Adlay seed; Antitumor; HeLa; HepG2; SGC-7901; DNA topoisomerase I; MA-YUEN STAPF; PHENOLIC-COMPOUNDS; IN-VITRO; ADLAY; SEED; APOPTOSIS; EXTRACT; LUNG;

D O I：

10.1016/j.fbio.2021.101047

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Coix lacryma-jobi L. is a traditional Chinese medicine, and has been investigated to treat inflammatory diseases and rheumatism. An antitumor active compound was isolated from the stems and leaves of Coix lacryma-jobi L. The molecular weight of this compound was 410 using mass spectrum analysis. The structural identification of the purified compound was determined using ultraviolet spectroscopy, Fourier transform infrared spectroscopy and nuclear magnetic resonance spectra, which showed that the compound was (20R)-22E-24-ethylcholesta-4,22-dien-3-one. HeLa, HepG2 and SGC-7901 cells for survival had a minimum IC50 values with this compound of 23.8, 67.6 and 25.5 mu g/mL, respectively. The compound had pro-apoptotic effects on three types of tumor cells, and had an inhibitory effect on DNA topoisomerase I. The effect was concentration dependent, but the compound did not cleave the DNA. The structure-activity relationship and action mechanism were explored, to provide a specific basis for the synthesis and development of antitumor drugs.

引用

页数：8

共 39 条

[1] Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells [J].

Amen, Yhiya ;

Arung, Enos Tangke ;

Afifi, Mohamed S. ;

Halim, Ahmed F. ;

Ashour, Ahmed ;

Fujimoto, Ryoji ;

Goto, Takahiro ;

Shimizu, Kuniyoshi .

NATURAL PRODUCT RESEARCH, 2017, 31 (23) :2712-2718

[2]

Bhandari S. R., 2012, African Journal of Biotechnology, V11, P1872

[3]

Cao G. C., 2007, J CLIN MED PRACTICE, V11, P1

[4] Antiproliferative and chemopreventive effects of adlay seed on lung cancer in vitro and in vivo [J].

Chang, HC ;

Huang, YC ;

Hung, WC .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (12) :3656-3660

[5]

Chen Han, 2014, Zhongguo Zhong Yao Za Zhi, V39, P3905

[6] Antimutagenic Constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with Potential Cancer Chemopreventive Activity [J].

Chen, Huang-Hui ;

Chiang, Wenchang ;

Chang, Jang-Yang ;

Chien, Ya-Lin ;

Lee, Ching-Kuo ;

Liu, Ko-Jiunn ;

Cheng, Yen-Ting ;

Chen, Ting-Fang ;

Kuo, Yueh-Hsiung ;

Kuo, Ching-Chuan .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (12) :6444-6452

[7] Adlay Seed (Coix lacryma-jobi L.) Extracts Exhibit a Prophylactic Effect on Diet-Induced Metabolic Dysfunction and Nonalcoholic Fatty Liver Disease in Mice [J].

Chiang, Hao ;

Lu, Hsu-Feng ;

Chen, Jui-Chieh ;

Chen, Yu-Hsin ;

Sun, Hsi-Tai ;

Huang, Hsiu-Chen ;

Tien, Hsiao-Hsuan ;

Huang, Cheng .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020

[8] Antiproliferative Lactams and Spiroenone from Adlay Bran in Human Breast Cancer Cell Lines [J].

Chung, Cheng-Pei ;

Hsu, Chih-Ying ;

Lin, Jing-Hui ;

Kuo, Yueh-Hsiung ;

Chiang, Wenchang ;

Lin, Yun-Lian .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (04) :1185-1194

[9]

Cui H. B., 2008, J HEILONGJIANG BAYI, V20, P66

[10] Phytochemistry and health promoting effects of Job's tears (Coix lacryma-jobi) - A critical review [J].

Devaraj, Ramya D. ;

Jeepipalli, Syam P. K. ;

Xu, Baojun .

FOOD BIOSCIENCE, 2020, 34

← 1 2 3 4 →