New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris

被引：104

作者：

Wu, TS ^{[1
]}

Tsang, ZJ

Wu, PL

Lin, FW

Li, CY

Teng, CM

Lee, KH

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

[2] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan

[3] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0968-0896(00)00225-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new constituents including a flavonoid, artemisidin A (1), and four coumarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated and characterized from the aerial part of Artemisia capillaris. The structures of these compounds were determined from spectral analyses and/or chemical evidence. Among them, 15 compounds (3, 6, 10, 18, 30-32, 38-41, 44, 45, 51, and 55) showed antiplatelet aggregation activity and three compounds (10, 17, and 51) demonstrated significant activity against HIV replication in H9 lymphocytic cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：77 / 83

页数：7

共 52 条

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