Diorgano, dichloro-tin (IV) complexes of 4-X-benzohydroxamic acid (X=Cl, OCH3):: Synthesis, characterization, antitumor activity in vitro and the crystal structure of trans- [Me2Sn (L2)2]

A series of diorganotin (IV) derivatives of R2SnL2 (R = Me, Et, n-Bu, ph or Cl; L = L, or L-2) and their corresponding mixed-ligand complexes R2Sn (L,)(L2) have been prepared and the structure of trans-Me2Sn (L-2)(2) was characterized by FT-IR, H-1, C-13 and Sn-119 NMR spectroscopies, MS, elemental analysis, melting points and X-ray diffraction. The structure-activity relationships were discussed.