Design and synthesis of phosphotyrosine mimetics

被引：14
|
作者：
Yan, Z
Kahn, M
Qabar, M
Urban, J
Kim, HO
Blaskovich, MA
机构：
[1] Molecumet Ltd, Bellevue, WA 98005 USA
[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[3] Pacific NW Res Inst, Seattle, WA 98122 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(03)00253-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Selective inhibitors of protein tyrosine phosphatases (PTPases) are of great interest as therapeutic agents and research tools. Several phenylalanine derivatives (1, 2) designed as phosphotyrosine mimetics or irreversible active site inhibitors were successfully synthesized, then incorporated into a combinatorial,library based on a peptidomimetic beta-strand template. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2083 / 2085
页数：3
相关论文
共 50 条
  • [1] A general and convenient synthesis of novel phosphotyrosine mimetics
    Szardenings, AK
    Gordeev, MF
    Patel, DV
    TETRAHEDRON LETTERS, 1996, 37 (21) : 3635 - 3638
  • [2] Design and synthesis of phosphotyrosine peptidomimetic prodrugs
    Garrido-Hernandez, Hugo
    Moon, Kyung D.
    Geahlen, Robert L.
    Borch, Richard F.
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (11) : 3368 - 3376
  • [3] Design and synthesis of α-helical peptides and mimetics
    Garner, James
    Harding, Margaret M.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (22) : 3577 - 3585
  • [4] Design and synthesis of dimeric heparinoid mimetics
    Rele, SM
    Iyer, SS
    Baskaran, S
    Chaikof, EL
    JOURNAL OF ORGANIC CHEMISTRY, 2004, 69 (26): : 9159 - 9170
  • [5] DESIGN AND SYNTHESIS OF NONPEPTIDE MIMETICS OF JASPAMIDE
    KAHN, M
    NAKANISHI, H
    SU, T
    LEE, JYH
    JOHNSON, ME
    INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1991, 38 (04): : 324 - 334
  • [6] DESIGN AND SYNTHESIS OF HYPERTREHALOSEMIC HORMONE MIMETICS
    SATO, M
    KAHN, M
    LIN, ZL
    JOHNSON, ME
    HAYES, TK
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (06) : 1277 - 1282
  • [7] DESIGN AND SYNTHESIS OF NONPEPTIDE MIMETICS OF ENKEPHALIN
    KAHN, M
    PATEL, C
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 199 : 304 - ORGN
  • [8] THE DESIGN AND SYNTHESIS OF PEPTIDE MIMETICS AND CHIMERAS
    KAHN, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 198 : 78 - MEDI
  • [9] Facile syntheses of building blocks for the construction of phosphotyrosine mimetics
    Cockerill, GS
    Easterfield, HJ
    Percy, JM
    Pintat, S
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (16): : 2591 - 2599
  • [10] Fragment-Based, Photoactive Phosphotyrosine Peptide Mimetics
    Rademann, J.
    Wagner, S.
    Horatscheck, A.
    JOURNAL OF PEPTIDE SCIENCE, 2012, 18 : S35 - S35
12345