SPOP tips the balance of BETs in cancer

被引：4

作者：

Fennell, Katie A. ^{[1
,2
]}

Dawson, Mark A. ^{[1
,2
,3
,4
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Res Div, Melbourne, Vic, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[3] Univ Melbourne, Ctr Canc Res, Melbourne, Vic, Australia

[4] Peter MacCallum Canc Ctr, Dept Haematol, Melbourne, Vic, Australia

来源：

NATURE MEDICINE | 2017年 / 23卷 / 09期

关键词：

PROSTATE-CANCER; RESISTANCE; MUTATIONS;

D O I：

10.1038/nm.4398

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer.

引用

页码：1014 / 1015

页数：2

共 11 条

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