Induction of SP1-3 mRNA, encoding a serine protease inhibitor, in gerbil hippocampus after transient forebrain ischemia

被引：20
|
作者：
Tsuda, M
Kitagawa, K
Imaizumi, K
Wanaka, A
Tohyama, M
Takagi, T
机构：
[1] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 1,OSAKA,JAPAN
[2] OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI,OSAKA,JAPAN
[3] TANABE SEIYAKU CO LTD,LEAD GENERAT RES LAB,OSAKA,JAPAN
来源：
MOLECULAR BRAIN RESEARCH | 1996年 / 35卷 / 1-2期
关键词：
ischemia; differential display; SPI-3; astrocyte;
D O I：
10.1016/0169-328X(95)00211-A
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We cloned genes the expression of which is induced in the Mongolian gerbil (Meriones unguiculatus) hippocampus after transient forebrain ischemia by a differential display technique. Among these genes, a rat serine protease inhibitor SPI-3 homologue was isolated. Present analyses suggested that the expression of gerbil SPI-3 mRNA was closely associated with delayed neuronal death and may block activities of proteases leaking from degenerating neurons or may support neuronal survival.
引用
收藏
页码：314 / 318
页数：5
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